Volume 2.09 | Mar 14

Dermal Cell News 2.09 March 14, 2016
Dermal Cell News
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Scaling up Tissue Engineering
Investigators invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells. The resulting network of vasculature contained within these deep tissues enables fluids, nutrients and cell growth factors to be controllably perfused uniformly throughout the tissue. [Press release from Wyss Institute discussing online prepublication in Proceedings of the National Academy of Sciences USA]
Press Release | Video | Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Twist1-Induced Activation of Human Fibroblasts Promotes Matrix Stiffness by Upregulating Palladin and Collagen α1(VI)
The authors found that human fibroblast cell lines stably transfected with Twist1 acquired characteristics of activated cancer-associated fibroblasts, such as hyperproliferation, an increased ability to migrate and an alignment of the actin cytoskeleton. [Oncogene] Abstract

Cartilage Oligomeric Matrix Protein Increases in Photodamaged Skin
Investigators examined how photoaging damage relates to cartilage oligomeric matrix protein (COMP) expression and localization in photoaged skin. In situ hybridization revealed an increase in COMP-mRNA-positive cells with the progress of photoaging in preauricular skin. [J Invest Dermatol] Abstract

A Factor VIIa Variant with Enhanced Tissue Factor Independent Activity Speeds Wound Healing in a Mouse Hemophilia B Model
Researchers hypothesized that a single dose of DVQ would be more effective in restoring wound healing in hemophilia B (HB). Healing times in HB mice treated with an equally hemostatic dose of DVQ were normalized to that of wild type animals. [J Thromb Haemost] Abstract

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch
Researchers addressed the question whether TRPV4 in skin keratinocytes functions in itch, as a particular form of forefront signaling in non-neural cells. Their results support this novel concept, based on attenuated scratching behavior in response to histaminergic, not non-histaminergic (chloroquine) pruritogens in Trpv4 keratinocyte-specific and inducible knockout mice. [J Biol Chem] Abstract | Press Release

Estrogen Accelerates Cutaneous Wound Healing by Promoting Proliferation of Epidermal Keratinocytes via Erk/Akt Signaling Pathway.
Scientists demonstrated that one of the critical mechanisms underlying 17 β-estradiol promoting skin wound healing is through regulation of keratinocyte proliferation via Erk/Akt signaling pathway. [Cell Physiol Biochem] Full Article

The Transcription Factor TBX2 Regulates Melanogenesis in Melanocytes by Repressing Oca2
Researchers found that α-MSH or forskolin, both of which stimulate melanogenesis, also reduce TBX2 expression, and that specific knockdown of TBX2 increases melanogenesis. [Mol Cell Biochem] Abstract


Development of Edge-Activated Liposomes for siRNA Delivery to Human Basal Epidermis for Melanoma Therapy
By providing direct quantitative and qualitative microscopy evidence, researchers demonstrated that the passive delivery of an edge-activated liposomal formulation can effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/upper dermis. [J Control Release] Abstract

In Vitro and In Vivo Anti-Tumor Activity of CoQ0 against Melanoma Cells: Inhibition of Metastasis and Induction of Cell-Cycle Arrest and Apoptosis through Modulation of Wnt/β-Catenin Signaling Pathways
Scientists found that coenzyme Q0 (CoQ0) treatment caused G1 cell-cycle arrest by reducing the levels of cyclin E and CDK4. CoQ0 treatment induced apoptosis through caspase-9/-3 activation, PARP degradation, Bcl-2/Bax dysregulation, and p53 expression. [Oncotarget] Full Article

Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells
Investigators used two-dimensional and organotypic melanoma culture models in combination with fluorescent cell cycle indicators to investigate the effects of cell cycle phases on clinically used drugs. [J Invest Dermatol] Abstract

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Hyaluronan: More than Just a Wrinkle Filler
Current knowledge about the role of hyaluronan in skin inflammation and wound healing are reviewed and possible future applications of such knowledge discussed. [Glycobiology] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Heat Biologics Presents Positive ComPACT Preclinical Data at the Keystone Symposia
Heat Biologics, Inc. announced that positive preclinical data from its next generation ComPACT platform technology, which combines a T cell priming vaccine and T cell co-stimulator in a single product, were presented. [Press release from Heat Biologics, Inc. discussing research presented at the Keystone Symposia on Cancer Vaccines: Targeting Cancer Genes for Immunotherapy, Whistler] Press Release

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Alliance for Cancer Gene Therapy Announces Three New Grant Awardees for Cancer Research
Alliance for Cancer Gene Therapy (ACGT) announced the recipients of its 2016 ACGT Young Investigator Grants. These grants are awarded to help the researchers build upon earlier research and take them to the next level in cancer treatment, setting the stage for possible clinical trials. [Alliance for Cancer Gene Therapy (EurekAlert!)] Press Release

FDA Accepts Amgen’s Supplemental Biologics License Application For The Expanded Use Of Enbrel® (Etanercept) To Treat Pediatric Patients With Chronic Severe Plaque Psoriasis
Amgen announced that the U.S. Food and Drug Administration (FDA) has accepted for review Amgen’s supplemental Biologics License Application for the expanded use of Enbrel® to treat pediatric patients with chronic severe plaque psoriasis. [Amgen] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Worldwide Innovative Networking in Personalized Cancer Medicine (WIN) 2016
July 27-28, 2016
Paris, France

Visit our events page to see a complete list of events in the dermal cell community.
NEW Senior Postdoctoral Researcher – Uveal Melanoma (Institut Curie)

NEW Postdoctoral Researcher – Skin Biology and Mitochondria (Karolinska Institutet)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

Assistant Professor – Regenerative Medicine (Ming Wai Lau Center for Regenerative Medicine)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Faculty Position – Melanoma and Immunotherapy (Weill Cornell College of Medicine)

Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

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