Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Precise and Scalable Self-Organization in Mammalian Pseudo-Embryos

[Nature Structural & Molecular Biology] Scientists investigated how precise and reproducible patterns of gene expression emerged in mammals by using gastruloids, a three-dimensional in vitro model for early mammalian development.

High Expression of miR-6785-5p in the Serum Exosomes of Psoriasis Patients Alleviates Psoriasis-Like Skin Damage by Interfering with the MNK2/p-eIF4E Axis in Keratinocytes

[Inflammation] Researchers employed qRT-PCR and fluorescence in situ hybridization to evaluate miR-6785-5p in psoriatic keratinocytes and conducted a microRNA microarray for identifying differentially expressed miRNAs in patient serum exosomes.

DPM1 Modulates Desmosomal Adhesion and Epidermal Differentiation through SERPINB5

[Journal Of Cell Biology] In a 3D organotypic human epidermis model, loss of DPM1 caused impaired differentiation with abnormally increased cornification, reduced thickness of non-corneal layers, and formation of intercellular gaps in the epidermis.

Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle-Shaped Microfluidic Device

[Advanced Healthcare Materials] After examining various dermal ECM molecules, investigators found that pluripotent stem cell-derived skin organoids generated in collagen type I supplemented with laminin 511 exhibited increased growth compared to conventional free-floating condition, but failed to induce complete skin differentiation due in part to necrosis.

The MITF/Mir-579-3p Regulatory Axis Dictates BRAF-Mutated Melanoma Cell Fate in Response to MAPK Inhibitors

[Cell Death & Disease] Researchers showed that miR-579-3p was specifically deregulated in BRAF-mutant melanomas and that its expression levels mirrored those of microphthalmia-associated transcription factor (MITF).

Sarcomeric Tropomyosin Expression during Human iPSC Differentiation into Cardiomyocytes

[Cytoskeleton] During the differentiation time course, researchers harvested cells on days 0, 5, 10, 15, and 20 to analyze for various sarcomeric tropomyosin (TPM) transcripts by qRT-PCR and for sarcomeric TPM proteins using two-dimensional Western blot with sarcomeric TPM-specific CH1 monoclonal antibody followed by mass spectra analyses.

Unraveling Lipid Metabolism Reprogramming for Overcoming Drug Resistance in Melanoma

[Biochemical Pharmacology] The authors discuss research progress on lipid metabolism in melanoma, and emphasize the dynamic ability of metabolism during tumorigenesis as a target for improving response to different therapies and for overcoming drug resistance in melanoma.

Age-Dependent Loss of HAPLN1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma

[Nature Aging] Investigators showed that HAPLN1 in the dermal extracellular matrix was sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression.

SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cells Migration to Epidermis through p53/SCF/C-KIT Signaling

[Journal Of Investigative Dermatology] Scientists demonstrated that after SPRY1 knockout in epidermal keratinocytes, melanocyte stem cells in the hair follicle exit the niche without depleting the pool of these cells.

Tumor-Intrinsic Galectin-3 Suppresses Melanoma Metastasis

[Journal Of Investigative Dermatology] The authors explored extracellular galectin-3 expression in human melanoma tissues as well as murine melanoma models to examine its causal role in metastatic behavior.

Cancer Researchers Awarded $3.2 Million Grant to Find Better Ways to Treat Advanced Melanoma

[UCLA Health] A team of investigators from the UCLA Health Jonsson Comprehensive Cancer and the University of Arkansas for Medical Sciences Winthrop P. Rockefeller Cancer Institute was awarded a $3.2 million grant from the National Institutes of Health to identify new ways to prevent and overcome treatment resistance to targeted therapy in patients with all sub-types of cutaneous melanoma.

Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices

[Science] Investigators discovered that without resolving lineage plasticity, skin stem cells could not effectively generate each lineage in vitro nor regrow hair and repair wounded epidermis in vivo.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.

spot_img