Volume 1.23 | Nov 9

Dermal Cell News 1.23 November 9, 2015
Dermal Cell News
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More than Skin Deep: Researchers Discover New Way to Help Skin Heal Faster
Researchers discovered a new way to prevent inflammation and to speed up the skin’s healing process. They identified the gene regulation pathway, which involves the body’s sodium sensor called Nax (scn7a) that triggers inflammation. They found a way to block it using a nanoparticle-carried small interference RNA, which enables the skin to heal faster. [Press release from Louisiana State University discussing online prepublication in Science Translational Medicine] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

MITF and C-Jun Antagonism Interconnects Melanoma Dedifferentiation with Pro-Inflammatory Cytokine Responsiveness and Myeloid Cell Recruitment
Investigators used functional genomic approaches and identified a reciprocal antagonism between the melanocyte lineage transcription factor MITF and c-Jun, which interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment. [Nat Commun] Full Article

Lactobacillus rhamnosus GG Lysate Increases Re-Epithelialization of Keratinocyte Scratch Assays by Promoting Migration
Scientists determined whether probiotic bacteria or their extracts could be beneficial in cutaneous wound healing. [Sci Rep] Full Article

The Cytolinker Plectin Regulates Nuclear Mechanotransduction in Keratinocytes
Investigators examined how cross-talk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. [J Cell Sci] Abstract

TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles
Using a cDNA expression assay, investigators discovered that TR3 is significantly enriched in human telogen bulge compared with anagen bulb. [Lab Invest] Abstract

Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane
The authors analyzed the effect of a stretch on keratinization of the epidermis and on the basement membrane. [PLoS One] Full Article


NUP160-SLC43A3 Is a Novel Recurrent Fusion Oncogene in Angiosarcoma
The specific driver mutations in angiosarcoma remain unknown. Scientists investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells, identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. [Cancer Res] Abstract | Press Release

Human Papillomavirus Mediated Inhibition of DNA Damage Sensing and Repair Drives Skin Carcinogenesis
The authors showed that cells expressing E6 fail to sense and mount an effective response to repair UV-induced DNA lesions and demonstrated a physiological relevance of E6-mediated inhibition of DNA damage repair for tumor initiation. [Mol Cancer] Full Article

Melanocytes Are More Responsive to IFN-γ and Produce Higher Amounts of Kynurenine than Melanoma Cells
Researchers measured kynurenine pathway (KP) metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to interferon-γ (IFN-γ). IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment. [Biol Chem] Abstract

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Silk Sericin: A Versatile Material for Tissue Engineering and Drug Delivery
The authors summarize the recent advancements in the study of silk sericin for application in tissue engineering and drug delivery. [Biotechnol Adv] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Osiris Therapeutics Announces an Addition to its Wound Care Portfolio, TruSkin™
Osiris Therapeutics, Inc. announced the launch of TruSkin™, a cryopreserved, living skin allograft. [Osiris Therapeutics, Inc.] Press Release

MD Anderson’s Moon Shots Mission Grows to Confront Six More Cancer Types
MD Anderson’s Moon Shots Program, an unprecedented effort and novel organizational model designed to more rapidly convert scientific discoveries into life-saving advances, has expanded its targets, adding several of the most intractable cancers to its campaign. [The University of Texas MD Anderson Cancer Center] Press Release

UTA Leads Technology to Create SMART Bandage Tool to Help Monitor, Heal Wounds
The University of Texas at Arlington is developing a sensing and therapeutic tool that will help doctors and other healthcare workers better monitor and heal patients’ complex wounds more quickly. [University of Texas at Arlington] Press Release

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Culture 2016
February 2-4, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the dermal cell community.
NEW Computational Biologist – UV Irradiation and Melanoma (Cancer Research UK Manchester Institute)

Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)

Postdoctoral Associate – Dermatology (University of Pittsburgh)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Medicinal Chemistry (Auburn University)

Independent Junior Group Leader – Human Genetics of Inflammatory Skin Diseases (University of Lübeck)

Postdoctoral Position – Cancer and Developmental Biology (University of California, Irvine)

Assistant Professor – Stem Cell Biology (University of South Carolina)

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