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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte-Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Dermavant Announces FDA Acceptance of Supplemental New Drug Application (sNDA) for VTAMA® (Tapinarof) Cream, 1% for the Treatment of Atopic Dermatitis in Adults and...
[Dermavant Sciences, Inc.] Dermavant Sciences, Inc. announced that the US FDA accepted the company’s sNDA for VTAMA® cream, 1% for the topical treatment of atopic dermatitis in adults and children two years of age and older.
Skin Graft with Dermis and Appendages Generated In Vivo by Cell Competition
[Nature Communications] Scientists generated complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos’ dermis.
Ribosomal S6 Kinase 2-Forkhead Box Protein O4 Signaling Pathway Plays an Essential Role in Melanogenesis
[Scientific Reports] Investigators reported that α-melanocyte-stimulating hormone, not ultraviolet (UV) UVA and UVB, acted as a major stimulus of melanogenesis in melanoma cells.
The Involvement of RIPK4 in TNF-α-Stimulated IL-6 and IL-8 Production by Melanoma Cells
[Journal Of Cancer Research And Clinical Oncology] The authors examined the effects of receptor-interacting protein kinase (RIPK4) downregulation on the transcriptomic profile of melanoma, and revealed a complex role for RIPK4 in regulating the immune signaling network in melanoma cells.
Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
[Pigment Cell & Melanoma Research] Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte stem cells at high resolution.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte- Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Cell Death as an Architect of Adult Skin Stem Cell Niches
[Cell Death & Differentiation] Investigators described how regulated cell death modalities functionally affect epidermal SC niches along with their relevance to injury repair, inflammatory skin disorders and cancer.
Lipid-Based Nanoparticles as a Promising Treatment for the Skin Cancer
[Heliyon] Scientists examine the properties and applications of nanoliposomes used in the treatment and prevention of numerous types of skin cancer.
Exploring the Mechanism of Huanglian Ointment in Alleviating Wound Healing After Anal Fistula Surgery through Metabolomics and Proteomics
[Heliyon] The S. aureus infected wound in SD rats were used to imitate poor healing wound after anal fistula surgery. SD rats with wound sites were randomly divided into four groups.
Overcoming BRAF and CDK4/6 Inhibitor Resistance by Inhibiting MAP3K3-Dependent Protection Against YAP Lysosomal Degradation
[Experimental & Molecular Medicine] Researchers identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the yes-associated protein (YAP) protein level in melanoma and breast cancer cells.
PARP1 Expression Predicts PARP Inhibitor Sensitivity and Correlates with Metastatic Potential and Overall Survival in Melanoma
[International Journal Of Cancer] The authors found that melanoma cells with high basal poly (ADP-ribose) polymerase (PARP1) expression exhibited significantly increased cell death after PARP inhibitor treatment, owing to higher PARP1 trapping compared with melanoma cells with low PARP1 expression.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
