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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
[Pigment Cell & Melanoma Research] Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte stem cells at high resolution.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte- Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Cell Death as an Architect of Adult Skin Stem Cell Niches
[Cell Death & Differentiation] Investigators described how regulated cell death modalities functionally affect epidermal SC niches along with their relevance to injury repair, inflammatory skin disorders and cancer.
Lipid-Based Nanoparticles as a Promising Treatment for the Skin Cancer
[Heliyon] Scientists examine the properties and applications of nanoliposomes used in the treatment and prevention of numerous types of skin cancer.
Exploring the Mechanism of Huanglian Ointment in Alleviating Wound Healing After Anal Fistula Surgery through Metabolomics and Proteomics
[Heliyon] The S. aureus infected wound in SD rats were used to imitate poor healing wound after anal fistula surgery. SD rats with wound sites were randomly divided into four groups.
Overcoming BRAF and CDK4/6 Inhibitor Resistance by Inhibiting MAP3K3-Dependent Protection Against YAP Lysosomal Degradation
[Experimental & Molecular Medicine] Researchers identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the yes-associated protein (YAP) protein level in melanoma and breast cancer cells.
PARP1 Expression Predicts PARP Inhibitor Sensitivity and Correlates with Metastatic Potential and Overall Survival in Melanoma
[International Journal Of Cancer] The authors found that melanoma cells with high basal poly (ADP-ribose) polymerase (PARP1) expression exhibited significantly increased cell death after PARP inhibitor treatment, owing to higher PARP1 trapping compared with melanoma cells with low PARP1 expression.
Epidermal Retinol Dehydrogenases Cyclically Regulate Stem Cell Markers and Clock Genes and Influence Hair Composition
[Communications Biology] Scientists demonstrated that all-trans-retinoic acid (ATRA) signaling cycles during hair follicle regeneration. This pattern was disrupted by genetic deletion of epidermal retinol dehydrogenases 2 (RDHE2) and RDHE2-similar that catalyzed the rate-limiting step in ATRA biosynthesis.
Extracellular Vesicles Released by Keratinocytes Regulate Melanosome Maturation, Melanocyte Dendricity, and Pigment Transfer
[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors showed that keratinocyte extracellular vesicles enhanced the ability of melanocytes to generate dendrites and mature melanosomes and promoted their efficient transfer.
Energy Metabolism As Therapeutic Target for Aged Wound Repair by Engineered Extracellular Vesicle
[Science Advances] Researchers demonsrated that metformin engineered extracellular vesicles could enhance aged mouse skin repair, as well as ameliorate cellular senescence and restore cell dysfunctions.
Genomic Deletions Explain the Generation of Alternative BRAF Isoforms Conferring Resistance to MAPK Inhibitors in Melanoma
[Cell Reports] Using different in vitro models of alternative BRAF mRNA isoforms (altBRAF)-mediated melanoma resistance, researchers demonstrated the production of altBRAFs exclusively from the BRAF V600E allele, correlating with corresponding genomic deletions.
Combined Therapy of Dabrafenib and an Anti-HER2 Antibody–Drug Conjugate for Advanced BRAF-Mutant Melanoma
[Cellular & Molecular Biology Letters] The authors evaluated the therapeutic efficacy of RC48, alone or in combination with dabrafenib, in BRAF-mutant cutaneous melanoma cell lines and cell-derived xenograft models.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
