Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Endocytic Activation and Exosomal Secretion of Matriptase Stimulate the Second Wave of EGF Signaling to Promote Skin and Breast Cancer Invasion

[Cell Reports] Investigators demonstrated a vesicular-trafficking-mediated interplay between matriptase and epidermal growth factor (EGF) signaling in skin and breast cancer promotion. EGF induced matriptase to undergo endocytosis together with the EGF receptor, followed by acid-induced activation in endosomes.

Anti-Cancer Mechanisms of Natural Isoflavones against Melanoma

[Heliyon] Scientists summarize the research progress of isoflavones in melanoma, including anti-melanoma roles and mechanisms of isoflavones via inhibition of tyrosinase activity, melanogenesis, melanoma cell growth, invasion of melanoma cells, and induction of apoptosis in melanoma cells.

ZEB1 Controls a Lineage-Specific Transcriptional Program Essential for Melanoma Cell State Transitions

[Oncogene] The authors performed a genome-wide characterization of ZEB1 transcriptional targets, by combining ChIP-sequencing and RNA-sequencing, upon phenotype switching in melanoma models.

Ketotifen Directly Modifies the Fibrotic Response of Human Skin Fibroblasts

[Scientific Reports] To determine direct effects on fibrotic fibroblasts, human dermal fibroblasts were treated with pro-fibrotic transforming growth factor-β1, followed by ketotifen or control treatments.

Cellular and Molecular Mechanisms of Skin Wound Healing

[Nature Reviews Molecular Cell Biology] The authors discuss the current understanding of the different phases of wound healing, from clot formation through re-epithelialization, angiogenesis and subsequent scar deposition.

Dermal Stiffness Governs the Topography of the Epidermis and the Underlying Basement Membrane in Young and Old Human Skin

[Aging Cell] Scientists presented an in-depth imaging analysis of basal keratinocyte anchorage in samples of human skin from participants across the age spectrum.

The Role of GAPDH in the Selective Toxicity of CNP in Melanoma Cells

[PLOS One] Treatment of melanoma cells and melanocytes with the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor heptelidic acid decreased viability to a much higher extent in the cancer cells than in the studied normal cells.

Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star

[Journal Of Investigative Dermatology] Scientists elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo.

VEGF/VEGFR Axis and Its Signaling in Melanoma: Current Knowledge toward Therapeutic Targeting Agents and Future Perspectives

[Life Sciences] The authors provide a comprehensive literature-based study on the VEGF/VEGFR axis in melanoma progression, diagnosis, and treatment.

Nuclear Localization of YAP Is Associated with Tumor Progression in Cutaneous Melanoma

[Laboratory Investigation] Flow cytometry, Western blotting, viability assays, and wound healing assays were conducted using melanoma cell lines subjected to YapS127A transfection and siYap knock-down.

Perspective Therapeutics Announces Clinical Collaboration Agreement with Bristol Myers Squibb to Evaluate [(212)Pb]VMT01 in Combination with Nivolumab in MC1R-Positive Metastatic Melanoma

[Perspective Therapeutics] Perspective Therapeutics, Inc. announced a clinical trial collaboration agreement with Bristol Myers Squibb to evaluate the safety and tolerability of Perspective's targeted alpha-particle therapy in combination with Bristol Myers Squibb's nivolumab in patients with histologically confirmed melanoma and positive melanocortin 1 receptor imaging scans.

KeChow Pharma Announces NMPA Approval of Tunlametinib as the First Targeted Therapy for Patients with NRAS Mutated Advanced Melanoma and Previously Treated with PD-1/PD-L1

[KeChow Pharma (BioSpace)] KeChow Pharma announced that the China National Medical Products Administration has approved tunlametinib for the treatment of patients with NRAS mutated advanced melanoma who were previously treated with PD-1/PD-L1.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.

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