Volume 2.11 | Mar 28

Dermal Cell News 2.11 March 28, 2016
Dermal Cell News
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Scientists Achieve Breakthrough in Diagnosis and Therapy of Melanoma Skin Cancer
Scientists revealed a remarkable link between malignant melanoma and a non-coding RNA gene called SAMMSON. The SAMMSON gene is specifically expressed in human malignant melanoma and, strikingly, the growth of aggressive skin cancer is highly dependent on this gene. [Press release from Flanders Institute for Biotechnology discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish
Researchers employed skinbow-based imaging in conjunction with a live reporter of epithelial stem cell cycle activity and as an instrument to evaluate the effects of reactive oxygen species on superficial epithelial cell behavior during epithelial regeneration. They introduced a platform for large-scale, quantitative in vivo imaging of regenerating skin and revealed unanticipated collective dynamism in epithelial cell size, mobility, and interactions. [Dev Cell] Full Article | Graphical Abstract | Press Release

Perlecan Expression Influences the Keratin 15-Positive Cell Population Fate in the Epidermis of Aging Skin
The authors revealed reduced perlecan transcript levels in aged keratinocytes. The production of in vitro skin models revealed that aged keratinocytes formed a thin and poorly organized epidermis. [Aging (Albany NY)] Full Article

5α-Dihydrotestosterone Enhances Wound Healing in Diabetic Rats
Researchers analyzed the effects of 5α-dihydrotestosterone ointment in cutaneous wound healing by secondary intention in diabetic Wistar rats. [Life Sci] Abstract


Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody
Investigators report an innovative self-degradable microneedle (MN) patch for the sustained delivery of anti-PD-1 (aPD1) in a physiologically controllable manner. They found that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. [Nano Lett] Abstract | Press Release

NFAT1 Directly Regulates IL-8 and MMP-3 to Promote Melanoma Tumor Growth and Metastasis
Researchers report a strong correlation between nuclear factor of activated T cell (NFAT1) expression and metastatic potential in melanoma cell lines and tumor specimens. To elucidate the mechanisms underlying NFAT1 overexpression during melanoma progression, they conducted a microarray on a highly metastatic melanoma cell line in which NFAT1 expression was stably silenced. [Cancer Res] Abstract

Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL-2 Regimen
Interleukin-adoptive cell transfer therapy with a reduced interleukin-2 (IL-2) decrescendo regimen resulted in long-lasting complete responses in patients with treatment-refractory melanoma. [Clin Cancer Res] Abstract

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression
Researchers report a key role of type I interferons (IFNs) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf did not exhibit senescence and develop aggressive melanomas. [Cell Rep] Full Article | Press Release

Inactivation of RASA1 Promotes Melanoma Tumorigenesis via R-Ras Activation
Scientists identified two novel, clustered somatic missense mutations in RASA1. They have shown that wild type RASA1, but not identified mutants, suppressed soft agar colony formation and tumor growth of BRAF mutated melanoma cell lines via its RasGAP activity toward R-Ras isoform. [Oncotarget] Full Article

NOD-Like Receptor Signaling and Inflammasome-Related Pathways Are Highlighted in Psoriatic Epidermis
Investigators assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5′-end RNA sequencing. [Sci Rep] Full Article

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HOPX: The Unusual Homeodomain-Containing Protein
In human skin, homeodomain-only protein homeobox (HOPX) controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions. [J Invest Dermatol] Full Article

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FDA Approves New Psoriasis Drug Taltz
The U.S. Food and Drug Administration approved Taltz (ixekizumab) to treat adults with moderate-to-severe plaque psoriasis. [U.S. Food and Drug Administration] Press Release

Cancer Center Awards First ‘Impact Grants’ for High-Risk, High-Reward Projects
Eleni Linos, MD, MPH, DrPH, and Stephen Francis, MS, PhD, have been awarded the first UCSF Cancer Center Impact Grants, to pursue high-risk, high-reward research projects that would’ve been unlikely to be funded through conventional mechanisms. [University of California, San Francisco] Press Release

ACell®, Inc. Receives FDA Clearance for Concurrent Use of Its Wound Management Devices
ACell, Inc. announced that it has received additional FDA clearance for its MicroMatrix® device, which describes the concurrent use of MicroMatrix® in conjunction with Cytal™ Wound Matrix or Cytal Burn Matrix devices. [ACell, Inc.] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 10th International Congress on Autoimmunity
April 6-10, 2016
Leipzig, Germany

Visit our events page to see a complete list of events in the dermal cell community.
NEW PhD Student – Immunology/Dermatology (University Hospital Heidelberg)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Senior Postdoctoral Researcher – Uveal Melanoma (Institut Curie)

Postdoctoral Researcher – Skin Biology and Mitochondria (Karolinska Institutet)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Faculty Position – Melanoma and Immunotherapy (Weill Cornell College of Medicine)

Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

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