Volume 2.10 | Mar 21

Dermal Cell News 2.10 March 21, 2016
Dermal Cell News
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Study Identifies Factors That Shape How Advanced Melanoma Responds to Immunotherapy
Researchers revealed how patterns of gene mutations and expression in a melanoma tumor before starting anti-PD-1 immunotherapy may forecast whether the tumor would shrink or the patient would derive survival benefits. [Press release from University of California, Los Angeles discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Cellular Forces and Matrix Assembly Coordinate Fibrous Tissue Repair
The authors developed a 3D biomimetic model for soft tissue repair and demonstrated that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24 hours. [Nat Commun] Full Article

Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles
Investigators used six transgenic reporters to isolate 14 major skin and hair follicle cell populations. With next-generation RNA sequencing, they characterized their transcriptomes and defined unique molecular signatures. [Cell Rep] Full Article | Graphical Abstract

Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis
The authors showed that YAP and TAZ are nuclear localized in the basal layer of skin and are elevated upon wound healing. Skin-specific deletion of both YAP and TAZ in adult mice slows proliferation of basal layer cells, leads to hair loss and impairs regeneration after wounding. [Development] Abstract

The Parkinsonism-Associated Protein DJ-1/Park7 Prevents Glycation Damage In Human Keratinocyte
The authors investigated the ability of DJ-1 to prevent protein glycation in keratinocytes. Glycation of collagen and keratinocyte proteins was tested by measuring ultraviolet absorption and fluorescence emission. [Biochem Biophys Res Commun] Abstract


Directed Migration of Cancer Cells by the Graded Texture of the Underlying Matrix
Researchers report a new type of directed migration—which they term ‘topotaxis’—guided by the gradient of the nanoscale topographic features in the cells’ extracellular matrix environment. [Nat Mater]
Abstract | Press Release

Inhibiting Drivers of Non-Mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy
Investigators examined the therapy phase before acquired resistance had developed and discovered the melanoma survival oncogene MITF as a driver of an early non-mutational and reversible drug-tolerance state, which is induced by PAX3-mediated upregulation of MITF. [Cancer Res]
Abstract | Graphical Abstract | Press Release

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2 Triggered Drug Resistance
Investigators report on the impact of class I histone deacetylase (HDAC) on the response of malignant melanoma cells treated with alkylating agents. The data showed that malignant melanomas in situ contain a high level of HDAC1/2 and malignant melanoma cells overexpress HDAC1/2/3 compared to non-cancer cells. [Cancer Cell] Abstract

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Scientists documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stages, and that phospho-FAK and BRAF are HSP70 client proteins. [Cancer Res] Abstract

Learn More: Standardized Tools for Cancer Research
Pericytes: A Newly Recognized Player in Wound Healing
The authors discuss pericyte involvement in wound repair and the relationship pericytes form with the parenchymal cells of the skin. [Wound Repair Regen] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Baylor College of Medicine, Baylor Scott & White Health Announce Collaboration on Biomedical Research
Baylor College of Medicine and Baylor Scott & White Health have entered into an agreement to expand biomedical research in North and Central Texas. [Baylor Scott & White Health] Press Release

Provectus Biopharmaceuticals Amends Protocol for Phase III Study of PV-10 in Treatment of Locally Advanced Cutaneous Melanoma
Provectus Biopharmaceuticals, Inc. announced that the protocol for its Phase III clinical trial for PV-10 as an investigational treatment for melanoma has been amended to reflect current and evolving standards of care and applicable patient population for a global study in melanoma. [Provectus Biopharmaceuticals, Inc.] Press Release

SRI International Receives $19.8 Million National Cancer Institute Contract for PREVENT Cancer Program
SRI International has been awarded a contract of up to $19.8 million from the National Cancer Institute PREVENT Cancer Preclinical Drug Development Program to support the development of potential cancer preventive agents or vaccines. [SRI International] Press Release

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NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the dermal cell community.
NEW Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Senior Postdoctoral Researcher – Uveal Melanoma (Institut Curie)

Postdoctoral Researcher – Skin Biology and Mitochondria (Karolinska Institutet)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Faculty Position – Melanoma and Immunotherapy (Weill Cornell College of Medicine)

Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

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