Volume 2.05 | Feb 15

Dermal Cell News 2.05 February 15, 2016
Dermal Cell News
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Hair Thinning by Stem Cell Loss
To better understand the role hair follicle stem cells might play in aging-associated hair loss, scientists studied hair follicles in a mouse model of accelerated hair loss. An analysis of the animals’ skin at 18 months, a stage when their hair loss begins, showed that their hair follicles were miniaturized and reduced in number and thickness. [Press release from American Association for the Advancement of Science (EurekAlert!) discussing online prepublication in Science] Press Release | Abstract 1 | Abstract 2
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PUBLICATIONS (Ranked by impact factor of the journal)

Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages
Sustained epidermal Wnt/β-catenin signaling expands the stem cell compartment and induces ectopic hair follicles. This is accompanied by extensive fibroblast proliferation and extracellular matrix remodeling in the underlying dermis. Scientists showed that epidermal hedgehog and transforming growth factor-beta signaling mediate the dermal changes. [Nat Commun] Full Article

Hierarchy of Cellular Decisions in Collective Behavior: Implications for Wound Healing
To determine which individual cell behaviors represent the most promising targets to engineer re-epithelialization, investigators examined collective and individual responses of HaCaT keratinocytes seeded upon polyacrylamide gels of three stiffnesses and treated with a range of epidermal growth factor doses. [Sci Rep] Full Article

Comparative Transcriptomic Profiling of Hydrogen Peroxide Signaling Networks in Zebrafish and Human Keratinocytes: Implications toward Conservation, Migration and Wound Healing
Comparative transcriptome analysis using RNA-seq data from larval zebrafish and previously reported microarray data from a human epidermal keratinocyte line showed that H2O2 activates conserved cell migration, adhesion, cytoprotective and anti-apoptotic programs in both zebrafish and human keratinocytes. [Sci Rep] Full Article

Nitric Oxide Chemical Donor Affects the Early Phases of In Vitro Wound Healing Process
An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 cells was used to analyze the effects of the nitric oxide chemical donor, S-nitroso-N-acetylpenicillamine. [J Cell Physiol] Abstract


Self-Targeting of TNF-Releasing Cancer Cells in Preclinical Models of Primary and Metastatic Tumors
The authors genetically engineered mouse mammary adenocarcinoma, melanoma, and Lewis lung carcinoma cells to produce and release murine tumor necrosis factor alpha (TNF). They showed that these malignant cells home to tumors, locally release TNF, damage neovascular endothelium, and induce massive cancer cell apoptosis. [Proc Natl Acad Sci USA] Abstract | Full Article

Primary and Metastatic Cutaneous Melanomas Express ALK through Alternative Transcriptional Initiation
Researchers determined whether anaplastic lymphoma kinase (ALK) was expressed in nonspitzoid primary and metastatic cutaneous melanomas. [Am J Surg Pathol] Abstract

Phosphorylation of eIF4E Serine 209 Is Associated with Tumor Progression and Reduced Survival in Malignant Melanoma
Researchers determined the association of eukaryotic translation initiation factor 4E (eIF4E) and phospho-eIF4E expression in melanocytic lesions with malignant conversion, metastatic potential and patient survival. [Br J Cancer] Abstract

Pluripotency Markers Are Differentially Induced by MEK Inhibition in Thyroid and Melanoma BRAFV600E Cell Lines
Cell line models of melanoma and thyroid carcinoma were treated with the MEK inhibitor PD0325901. Treated and naive samples were assayed for expression of key members of the MAPK pathway. [Cancer Biol Ther] Abstract

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Advances in Immunotherapy for Melanoma
The combination of ipilimumab and nivolumab has yielded higher response rates, greater tumor shrinkage, and longer progression-free survival than either monotherapy alone. As other promising immunotherapies for melanoma proceed through clinical trials, future goals include defining the role of immune checkpoint inhibitors as adjuvant therapy, identifying optimal combination strategies, and developing reliable predictive biomarkers to guide treatment selection for individual patients. [BMC Med] Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
NIH Awards $2.8 Million to FAU Researchers and Collaborators
Researchers will work to define the mechanisms governing how cells decide whether to become a mature cell or whether to die. Their work will shed light on how to make transplantable tissues to cure diseases. [Florida Atlantic University (FAU)] Press Release

Spectrum Awards More than $1 Million in Pilot Grants to 30 Projects
Stanford’s clinical and translational research center has awarded funding to teams of multidisciplinary investigators who are tackling health-care problems through novel approaches. [Stanford Medicine] Press Release

Chemence Medical Receives FDA Clearance for Exofin® Tissue Adhesive
Chemence Medical, Inc. announced it received Food and Drug Administration clearance to market and sell Exofin®, a new topical skin adhesive for wound closure. [Chemence Medical, Inc. (Business Wire)] Press Release

SBP Investigator Receives Outstanding Investigator Grant through New National Cancer Institute Program
A renowned cancer researcher at Sanford Burnham Prebys Medical Discovery Institute (SBP) has received a National Cancer Institute Outstanding Investigator Award for cancer research with breakthrough potential. [Sanford Burnham Prebys Medical Discovery Institute (Newswise, Inc.)] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW International Society for Stem Cell Research (ISSCR) 2016 Annual Meeting
June 22-25, 2016
San Francisco, United States

Visit our events page to see a complete list of events in the dermal cell community.
NEW Postdoctoral Position – Computational Biology of Inflammatory Skin Diseases (Helmholtz Association)

NEW Faculty Position – Melanoma And Immunotherapy (Weill Cornell College of Medicine)

NEW Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

Professor – Dermatology (Eberhard Karls Universität Tübingen)

Postdoctoral Research Scientist – Skin Wound Healing and Inflammation (Inserm)

Professor – Dermato-oncology (Rheinische Friedrich-Wilhelms-University of Bonn)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Postdoctoral Position – Regenerative Medicine (University of Copenhagen)

Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

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