Volume 2.02 | Jan 18

Dermal Cell News 2.02 January 18, 2016
Dermal Cell News
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Study Identifies Signals that Make Early Stem Cells
Researchers have identified a new mechanism by which cells are instructed during development to become stem cells. The results help explain how communication between cells mediates this process, and may have implications for skin cancer treatments. [Press release from The Rockefeller University discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation
The authors report that stimulation with zymosan or S. aureus induced MALT1 protease activity in human primary keratinocytes. [J Invest Dermatol] Abstract | Full Article

Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-Epithelialization
Researchers demonstrated that epidermal injury in murine skin does not induce bulge activation during early epidermal wound repair. [Stem Cells] Abstract

Substance P Enhances EPC Mobilization for Accelerated Wound Healing
Researchers demonstrated that neuropeptide substance P (SP) accelerates the wound healing process, particularly in the skin. Subcutaneous treatment of SP accelerated wound closing, increased the population of α-smooth muscle actin positive myofibroblasts, and increased extracellular matrix deposition at the wound site. [Wound Repair Regen] Abstract

Multipotency of Melanoblasts Isolated from Murine Skin Depends on the Notch Signal Pathway
Investigators showed that melanoblasts (MBs) isolated from mouse skin were multipotent, generating neurons and glial cells together with melanocytes. Using Sox10-IRES-Venus mice and mouse ES cells, they investigated how MBs expressed their multipotency. [Dev Dyn] Abstract


ΔNp63 Regulates IL-33 and IL-31 Signaling in Atopic Dermatitis
The authors showed that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in atopic dermatitis. [Cell Death Differ] Full Article

BRAF Inhibitor Resistance Enhances Vulnerability to Arginine Deprivation in Melanoma
Researchers demonstrated that BRAF inhibitor-resistant melanomas are susceptible to arginine deprivation due to inability to initiate re-expression of argininosuccinate synthetase as well as ineffective autophagy. [Oncotarget] Full Article

Acyl Protein Thioesterase 1 and 2 (APT-1, APT-2) Inhibitors Palmostatin B, ML348 and ML349 Have Different Effects on NRAS Mutant Melanoma Cells
Scientists investigated the expression and function of NRAS depalmitoylating APT-1 and APT-2 in a panel of NRAS mutant melanoma cells. They showed that all melanoma cell lines examined express APT-1 and APT-2.[Oncotarget] Full Article

Silvestrol Induces Early Autophagy and Apoptosis in Human Melanoma Cells
Investigators determined if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultured human cancer cells derived from solid tumors. [BMC Cancer] Full Article

A “Pedi” Cures All: Toenail Trimming and the Treatment of Ulcerative Dermatitis in Mice
Scientists hypothesized that interfering with scratching behavior by trimming the toenails of mice with ulcerative dermatitis (UD), would resolve UD lesions. They evaluated the efficacy of toenail trims with a single application of Vetericyn at the time of treatment versus the previous standard of care, topical Tresaderm applied daily. They found that toenail trims were significantly more effective at resolving lesions. [PLoS One]
Full Article | Press Release

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Connexin Channels in Congenital Skin Disorders
Gap junctions and hemichannels comprised of connexins influence epidermal proliferation and differentiation. Significant advances in the understanding of the functional role of connexins in the skin have been made by studying the diseases caused by connexin mutations. [Semin Cell Dev Biol] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Study Shows Topical BioPharmX Formulation Treats Acne while Minimizing Systemic Exposure of Minocycline
BioPharmX Corporation showed its unique formulation of minocycline, known as BPX-01, may offer a breakthrough in acne treatment because it may not result in systemic toxicities commonly associated with current use of the orally administered antibiotic. [Press release from BioPharmX Corporation discussing research presented at the 2016 Winter Clinical Dermatology Conference, Kauai] Press Release

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Provectus Biopharmaceuticals Confirms First Patients Dosed in Trials of PV-10 for Melanoma
Provectus Biopharmaceuticals, Inc. confirmed that patients have been dosed in both its Phase III clinical trial of PV-10, Provectus’ novel investigational drug for cancer, for stage III locally advanced cutaneous melanoma and its Phase Ib/II clinical trial of PV-10 in combination with Merck’s anti-PD-1 therapy KEYTRUDA® in patients with stage IV melanoma. [Provectus Biopharmaceuticals, Inc.] Press Release

BBI Receives Frost & Sullivan Award for New Product Innovation for Pressure Ulcer Diagnostics
BBI, LLC announced that it has won the Frost & Sullivan European New Product Innovation Award for Pressure Ulcer Diagnostics for 2015 for the SEM Scanner, BBI’s “revolutionary” hand-held device for detecting early pressure ulcers. [BBI, LLC] Press Release

ReNeuron Wins Major UK Grant to Advance Its Exosome Nanomedicine Platform
ReNeuron Group plc announced that it has been awarded a £2.1 million grant from Innovate UK to further advance its emerging exosome nanomedicine platform. The grant, entitled “Stem cell-derived exosomes for regenerative medicine”, has been awarded under Innovate UK’s Developing Regenerative Medicine & Cell Therapies’ grant scheme. [ReNeuron Group plc] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cancer as an Evolving and Systemic Disease
March 12-15, 2016
New York City, United States

Visit our events page to see a complete list of events in the dermal cell community.
NEW Postdoctoral Research Scientist – Skin Wound Healing and Inflammation (Inserm)

Postdoctoral Fellow – Skin Cancer (German Cancer Research Center)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Professor – Dermato-oncology (Rheinische Friedrich-Wilhelms-University of Bonn)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Position – Regenerative Medicine (University of Copenhagen)

Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

Research Fellow – Dermatology (Brigham and Women’s Hospital)

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