Volume 1.27 | Dec 7

Dermal Cell News 1.27 December 7, 2015
Dermal Cell News
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Skin Cells Play ‘Dice Games’
Scientists showed that all dividing skin cells can flip between two probability game modes and so have the potential to both maintain and heal skin, challenging the view that only rare stem cells matter. [Press release from the Wellcome Trust Sanger Institute (EurekAlert!) discussing online prepublication in Nature Cell Biology] Press Release | Abstract
Watch Video MesenTrek Rise of Enriched Mouse MSC Cultures
PUBLICATIONS (Ranked by impact factor of the journal)

Bone Marrow Mesenchymal Stem Cell Aggregate: An Optimal Cell Therapy for Full-Layer Cutaneous Wound Vascularization and Regeneration
Cell-aggregates constructed with green fluorescent protein-expressing rat bone marrow mesenchymal stem cells were applied to rat acute full-layer cutaneous wound model to confirm its pro-regeneration ability and compare its regenerative efficacy with the currently thriving subcutaneous and intravenous stem cell administration strategy, with a view to sensing the advantages, disadvantages and the mechanism behind. [Sci Rep] Full Article

Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and Differentiation
To investigate hyaluronan (HA) functions, scientists studied the effects of HA depletion on human keratinocyte physiology within in vitro reconstructed human epidermis. [J Biol Chem] Abstract | Full Article

Cellular Events during Scar-Free Skin Regeneration in the Spiny Mouse, Acomys
Investigators compared the responses of scarring and non-scarring organisms concentrating on the immune cells and wound cytokines, cell proliferation and the collagenous components of the wound bed and scar. [Wound Repair Regen] Abstract


Melanocyte Antigen Triggers Autoimmunity in Human Psoriasis
Researchers identified melanocytes as skin-specific target cells of an human leukocyte antigen (HLA)-C*06:02–restricted psoriatic T cell response. They found that a Vα3S1/Vβ13S1 T cell receptor specifically recognized HLA-C*06:02–positive melanocytes. [J Exp Med] Abstract

Donor-Derived Stem-Cells and Epithelial Mesenchymal Transition in Squamous Cell Carcinoma in Transplant Recipients
Investigators studied stem-cells and epithelial mesenchymal transition expression in skin squamous-cell-carcinomas and concomitant actinic keratoses in kidney-transplant recipients. [Oncotarget] Full Article

A Synthetic Modular Approach for Modeling the Role of the 3D Microenvironment in Tumor Progression
Tumor cell function was investigated by culturing WM239A melanoma cells on poly(ethylene glycol) hydrogel surfaces or encapsulating cells within the hydrogels, and either as monocultures or indirect cocultures with primary human dermal fibroblasts. [Sci Rep] Full Article

Downregulation of Pyrroline-5-Carboxylate Reductase-2 Induces the Autophagy of Melanoma Cells via AMPK/mTOR Pathway
Investigators focused on the effect of pyrroline-5-carboxylate reductase-2 (PYCR2) on inducing autophagy process in melanoma. They found that silencing PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. [Tumor Biol] Abstract

Master Regulators of Infiltrate Recruitment in Autoimmune Disease Identified through Network-Based Molecular Deconvolution
Using alopecia areata as a model, investigators adapted regulatory network analysis to specifically isolate physiological behaviors in the skin that contribute to the recruitment of immune cells in autoimmune disease. [Cell Syst] Full Article | Graphical Abstract

Learn More: Standardized Tools for Cancer Research
Collagen Interactions: Drug Design and Delivery
Strategies to target collagen interactions are already being developed, including the use of monoclonal antibodies to interfere with collagen fibril formation and the use of triple-helical peptides to direct liposomes to melanoma cells. Intelligent control of collagen biological interactions within a material context will expand the effectiveness of collagen-based drug delivery. [Adv Drug Deliv Rev] Abstract

Visit our reviews page to see a complete list of reviews in the Dermal Cell research field.
T-VEC Plus Pembrolizumab Combo Shows Activity in Advanced Melanoma
The combination of the attenuated oncolytic virus talimogene laherparepvec (T-VEC) and the immune checkpoint inhibitor pembrolizumab shows activity and is well tolerated by advanced melanoma patients. [Press release from Cancer Network discussing research presented at the Society for Melanoma Research (SMR) 2015 International Congress, San Francisco] Press Release

From our sponsor: Studying ESCs or iPSCs? Request your free copy of the small molecules wallchart.
Exelixis Announces European Commission Approval of COTELLIC™ (Cobimetinib) for Use in Combination with Vemurafenib in Advanced BRAF V600 Mutation-Positive Melanoma
Exelixis, Inc. announced that the European Commission has approved COTELLIC™ for use in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation. [Exelixis, Inc.] Press Release

Amgen’s First Biosimilar Biologics License Application for ABP 501 Submitted to U.S. Food and Drug Administration
Amgen announced the submission of a Biologics License Application with the United States (U.S.) Food and Drug Administration for ABP 501, a biosimilar candidate to Humira® (adalimumab). [Amgen, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cells and Organoids as Models of Tissue Differentiation and Disease
January 12, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the Dermal Cell community.
NEW Professor – Dermatology (Universität Tübingen)

NEW Group Leader Position – Cancer Research (Oslo University Hospital)

NEW Postdoctoral Position – Molecular Cancer Biology (University of Pennsylvania)

NEW PhD Position – Cancer Research and Wound Healing (Technion, Israel Institute of Technology)

Postdoctoral Researcher – Non-Coding RNAs and Skin Wound Healing (Karolinska Institutet)

Research Associate/Scientist – Dermato-Pharmacokinetics (Simcyp)

Senior Manager – Immunology (Baxalta Innovations GmbH)

Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)

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