Volume 1.14 | Aug 24

Dermal Cell News 1.14 August 24, 2015
Dermal Cell News
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Combined CSL and p53 Downregulation Promotes Cancer-Associated Fibroblast Activation
Investigators report that CSL silencing induced senescence of primary fibroblasts from dermis, oral mucosa, breast and lung. CSL functioned in these cells as a direct repressor of multiple senescence- and cancer-associated fibroblasts-effector genes. [Nat Cell Biol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Keratinocyte Microvesicles Regulate the Expression of Multiple Genes in Dermal Fibroblasts
Researchers investigated whether microvesicle-like structures are present in human wounds and whether they affect wound healing-associated gene expression in dermal fibroblasts. [J Invest Dermatol] Abstract

Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing and Wnt Activation
By examining endogenous Prominin-1/CD133 (Prom1) expression and expression of LacZ in the skin of Prom1CreERLacZ mice, investigators confirmed that Prom1 is expressed in the dermal papilla of all developing hair follicles and also by postnatal anagen follicles. [J Invest Dermatol] Abstract | Full Article

Vitamin D Induces Cyclooxygenase 2 Dependent Prostaglandin E2 Synthesis in HaCaT Keratinocytes
Treatment of human immortalized HaCaT keratinocytes with calcitriol increased prostaglandin E2 production due to increased mRNA and protein expression of COX-2, but not to increase of COX-1 or release of arachidonic acid. [J Cell Physiol] Abstract

Antibiotics in Cell Culture: Friend or Foe? Suppression of Keratinocyte Growth and Differentiation in Monolayer Cultures and 3D Skin Models
The authors investigated the effect of the most commonly used antibiotics; gentamycin and the combination of penicillin and streptomycin on keratinocyte growth and differentiation. [Exp Dermatol] Abstract

Vitamin D and Calcium Regulation of Epidermal Wound Healing
Mice lacking the vitamin D receptor when placed on a low calcium diet had delayed wound healing. This was associated with reduced β-catenin transcriptional activity and proliferation in the cells at the leading edge of wound closure. [J Steroid Biochem Mol Biol] Abstract

miR-526b Targets 3′ UTR of MMP1 mRNA
Using reporter constructs containing the 3′ untranslated region of matrix metalloproteinases 1 (MMP1) and its mutant form, scientists showed that the region from 377–383 in the 3′ UTR of MMP1 is critical for targeting by miR-526b. In addition, the expression pattern of miR-526b and MMP1 mRNA showed reverse relation between adult dermal and neonatal fibroblasts. [Exp Mol Med] Full Article


Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice
The authors found that Clock mutation ameliorated imiquimod (IMQ)-induced dermatitis whereas Period2 mutation exaggerated IMQ-induced dermatitis when compared with wild-type mice associated with decreased or increased IL-23 receptor expression in γ/δ+ T cells, respectively. [J Invest Dermatol] Full Article

The Transcription Cofactor c-JUN Mediates Phenotype Switching and BRAF Inhibitor Resistance in Melanoma
Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein kinase kinase (MEK), collectively BRAF/MEK inhibitors. Researchers found that inherent resistance to these agents in BRAF(V600)-mutant melanoma cell lines was associated with high abundance of c-JUN and characteristics of a mesenchymal-like phenotype. [Sci Signal] Abstract

Atypical Signaling of Metabotropic Glutamate Receptor 1 in Human Melanoma Cells
Investigators determined if the activation of a canonical G protein-dependent signal transduction cascade, which is often used as an output of metabotropic glutamate 1 (mGlu1) receptor activity in neuronal cells, correlated with mGlu1 receptor-mediated melanoma cell viability. [Biochem Pharmacol] Abstract | Graphical Abstract

Compound 13, an α1-Selective Small Molecule Activator of AMPK, Potently Inhibits Melanoma Cell Proliferation
Scientists studied the potential effect of Compound 13 (C13), a novel α1-selective AMP-activated protein kinase (AMPK) activator, in melanoma cells. C13 potently inhibited proliferation in melanoma cell lines, but not in B10BR melanocytes. [Tumor Biol] Abstract

Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
Nanomaterials for Wound Healing: Scope and Advancement
The authors summarize the recent progress in advanced therapy for cutaneous wound healing during last five years using a nanotechnology-based approach. [Nanomedicine] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Groundbreaking Anti-Aging Discovery at Summer Meeting of the American Academy of Dermatology
A team of research scientists from the Avon Skincare Institute presented a new breakthrough in anti-aging skincare at this week’s Summer Conference of The American Academy of Dermatology [Press release from Avon Products, Inc. discussing research presented at the Summer Conference of The American Academy of Dermatology, New York] Press Release

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OncoSec Announces First Patient Enrolled in Phase II Clinical Trial Evaluating Combination of ImmunoPulse™ IL-12 and Anti-PD-1 Treatment
OncoSec Medical Incorporated announced enrollment of the first patient into the Phase II Investigator Sponsored Trial led by the University of California, San Francisco to assess the anti-tumor activity, safety, and tolerability of the combination of OncoSec’s investigational therapy, ImmunoPulse™ IL-12, and Merck’s approved anti-PD-1 agent, KEYTRUDA®, in patients with unresectable metastatic melanoma. [OncoSec Medical Incorporated] Press Release

$52 Million NIH Grant Advances Clinical and Translational Research at UC San Diego
The Clinical and Translational Research Institute at University of California, San Diego has received a five-year Clinical and Translational Science Award for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health (NIH). [UC San Diego Health] Abstract

Janus Biotherapeutics Enters Collaboration with Roche in Autoimmune Diseases
Janus Biotherapeutics announced that they have entered into a collaboration with Roche for the development of a small molecule toll-like receptor inhibitor with the potential to address several autoimmune diseases. [Janus Biotherapeutics (PR Newswire Association LLC)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW War on Cancer 2015
October 20, 2015
London, United Kingdom

NEW Innovation and Biomarkers in Cancer Drug Development (IBCD)
December 3-4, 2015
Brussels, Belgium

Visit our events page to see a complete list of events in the dermal cell community.
NEW Research Associate – Skin Inflammation and Carcinogenesis (Imperial College London)

NEW Postdoctoral Scientist – Skin Microbiome (National Human Genome Research Institute)

Associate Professor/Professor – Dermatology (University of Texas MD Anderson Cancer Center)

Senior Manager Immunology – Immunology (Baxalta Innovations GmbH)

Assistant Professor – Cell Biology or Molecular and Cellular Mechanisms (Washington University School of Medicine)

PhD Position – Materials Engineering (IFP Energies Nouvelles)

Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

PhD Position – Biomedical Research (Macquarie University)

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