Volume 1.12 | Aug 10

Dermal Cell News 1.12 August 10, 2015
Dermal Cell News
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Researchers Identify Drug Candidate for Skin, Hair Regeneration among Scarred Victims of Burns and Trauma
Researchers have identified a novel cell signaling pathway in mice through which mammals—presumably including people—can regenerate hair follicles and skin while healing from wounds. [Press release from Johns Hopkins University discussing online prepublication in Cell Stem Cell]
Press Article | Full Article | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin
Using next-generation RNA sequencing, researchers defined gene expression patterns in the context of the entire embryonic skin, and through transcriptome cross-comparisons, they uncovered hundreds of enriched genes in cell-type-specific signatures. [Dev Cell] Abstract | Graphical Abstract

Pleiotropic Age-Dependent Effects of Mitochondrial Dysfunction on Epidermal Stem Cells
Investigators developed a mouse model that generates mitochondrial oxidative stress in keratin 14-expressing epidermal stem/progenitor cells in a temporally controlled manner owing to deletion of superoxide dismutase 2. [Proc Natl Acad Sci USA] Abstract | Press Release

The EGF Receptor Ligand Amphiregulin Controls Cell Division via FoxM1
Researchers showed that silencing of the epidermal growth factor (EGF)-related factor amphiregulin markedly inhibits the expansion of human keratinocytes through mitotic failure and accumulation of cells with greater than or equal to 4n DNA content. [Oncogene] Abstract

Pathogenic Cx31 Is Un/Misfolded to Cause Skin Abnormality via a Fos/JunB-Mediated Mechanism
Investigators showed that erythrokeratodermia variabilis pathogenic connexin-31 (Cx31) mutants are un/misfolded and temperature sensitive. In Drosophila, expression of pathogenic Cx31, but not wildtype Cx31, caused depigmentation and degeneration of ommatidia that are rescued by expression of either dBip or dHsp70. [Hum Mol Genet] Abstract

Preformed Gelatin Microcryogels as Injectable Cell Carriers for Enhanced Skin Wound Healing
Biological changes of human adipose-derived stem cells (hASCs) laden in gelatin microcryogels (GMs) were compared in varied aspects with traditional two dimensional cell culture, such as cell phenotype markers, stemness genes, differentiation, secretion of growth factors, cell apoptosis and cell memory. [Acta Biomater] Abstract

MicroRNAs Enhance Keratinocyte Proliferative Capacity in a Stem Cell-Enriched Epithelium
Using antagomirs-103/107, scientists knocked down endogenous miRs-103/107 in keratinocytes and conducted an mRNA profiling study. They showed that miRs-103/107 target mitogen-activated protein kinase kinase kinase 7 and thereby negatively regulate the p38/AP-1 pathway. [PLoS One] Full Article

Kcnh2 and Kcnj8 Interactively Regulate Skin Wound Healing and Regeneration
Using a mammalian model system that allowed them to determine differentially expressed genes when skin regenerates and when skin does not regenerate after wound induction, researchers identified two potassium channels, kcnh2 and kcnj8, to be differentially expressed between the two states and highly expressed after wound induction at the non-regenerative state. [Wound Repair Regen] Abstract


Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF
Scientists examined the changes in microenvironment that occur during melanoma radial growth. They showed that direct contact of melanoma cells with the remote epidermal layer triggers vertical invasion via Notch signaling activation, the latter serving to inhibit MITF function. [Mol Cell] Abstract | Graphical Abstract

FOXD3 Promotes PAX3 Expression in Melanoma Cells
Investigators defined a regulatory pathway where FOXD3 promotes the expression of PAX3. Both factors were expressed in melanoma cells and there was a positive correlation between the transcript levels of PAX3 and FOXD3. [J Cell Biochem] Abstract

SPARC Controls Melanoma Cell Plasticity through Rac1
The authors found that suppression of SPARC (Secreted Protein Acidic and Rich in Cysteine) expression in human melanoma cells compromised cell migration, adhesion, cytoskeleton structure, and cell size. [PLoS One] Full Article

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Pathogenesis and Targeted Treatment of Skin Injury in SLE
Skin is the second most common organ (after the kidney) to be affected in patients with systemic lupus erythematosus (SLE), yet the etiology of skin injury and the mechanisms involved in the development of dermal manifestations of SLE remain unclear. [Nat Rev Rheumatol] Abstract

Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine
The authors summarize the literature on dermis stem cells regarding their niches and the specific markers they express. The concept of the niches and the differentiation capacity of cells residing in them along particular lineages is discussed. Furthermore, the advantages and disadvantages of widely used methods to demonstrate lineage differentiation are considered. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Markey’s D’Orazio Receives Funding to Further Skin Cancer Research
The University of Kentucky’s Dr. John D’Orazio recently received grant funding totaling $375,000 over three years to further his research on melanoma, the deadliest form of skin cancer. [University of Kentucky] Press Release

Moffitt Cancer Center Teams Up with MD Anderson to Discover, Test Novel Agents to Prevent Cancer
Moffitt Cancer Center has joined MD Anderson’s National Cancer Institute (NCI) Phase 0/I/II Cancer Prevention Clinical Chemoprevention Trials Consortia. Sponsored by the NCI’s Division of Cancer Prevention, the consortia conducts early clinical development of promising new preventive agents through its Phase 0/I/II Cancer Prevention Clinical Trials Program. [Moffitt Cancer Center (Newswise, Inc.)] Abstract

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cells of the Skin: Target and Cure for Disease
October 29-30, 2015
Santander, Spain

NEW 10th International Congress on Autoimmunity
April 6-10, 2016
Leipzig, Germany

Visit our events page to see a complete list of events in the dermal cell community.
NEW Associate Professor/Professor – Dermatology (University of Texas MD Anderson Cancer Center)

NEW Senior Manager Immunology – Immunology (Baxalta Innovations GmbH)

NEW Assistant Professor – Cell Biology or Molecular and Cellular Mechanisms (Washington University School of Medicine)

NEW PhD Position – Materials Engineering (IFP Energies Nouvelles)

Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

Research Fellow – Tissue Engineering & Regenerative Medicine (National Cancer Center Singapore)

PhD Position – Biomedical Research (Macquarie University)

Scientific Writer – Regenerative Medicine (University of Washington)

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