Volume 1.03 | Jun 1

Dermal Cell News 1.03 June 1, 2015
Dermal Cell News
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Researchers Identify a New Target for Treating Drug-Resistant Melanoma
A new collaborative study provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs called BRAF inhibitors. The findings suggest that targeting newly discovered pathways could be an effective approach to improving the clinical outcome of patients with BRAF inhibitor-resistant melanoma tumors. [Press release from Sanford-Burnham discussing online prepublication in Cell Rep] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

RIPK1 Regulates Survival of Human Melanoma Cells Upon Endoplasmic Reticulum Stress Through Autophagy
The authors report that receptor [TNFRSF]-interacting protein kinase 1 (RIPK1) functions as an important prosurvival mechanism in melanoma cells undergoing pharmacological ER stress induced by tunicamycin or thapsigargin through activation of autophagy. [Autophagy] Abstract

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22
Using gain- and loss-of-function approaches in vivo, researchers found that miR-22 overexpression leads to hair loss by promoting anagen-to-catagen transition of the hair follicles, and that deletion of miR-22 delays entry to catagen and accelerates the transition from telogen to anagen. [PLoS Genet] Full Article

Combined Inhibition of MEK and Plk1 has Synergistic Anti-Tumor Activity in NRAS Mutant Melanoma
Scientists revealed that mutant neuroblastoma-RAS (NRAS) induced Plk1 expression, and pharmacologic inhibition of Plk1 stabilized the size of NRAS mutant melanoma xenografts. [J Invest Dermatol] Abstract

Artificial Extracellular Matrices Support Cell Growth and Matrix Synthesis of Human Dermal Fibroblasts in Macroporous 3D Scaffolds
Coatings with artificial extracellular matrix, consisting of the structural protein collagen I and the glycosaminoglycans hyaluronan (HA) or sulphated HA derivatives, were investigated for their applicability in a three-dimensional (3D) system. [J Tissue Eng Regen Med] Abstract

Transcriptional Control of Late Differentiation in Human Keratinocytes by TAp63 and Notch
Upon induction of differentiation of primary human keratinocytes, investigators observed endogenous expression of TAp63β and γ isoforms, along with transcriptional activation of selected target genes. [Exp Dermatol] Abstract

A Conditional Transgenic Mouse Line for Targeted Expression of the Stem Cell Marker LGR5
Investigators used transgenic mice to drive expression of LGR5 in the epidermis. Expression of human LGR5 was induced in the skin of double transgenic mice and inducing LGR5 expression during embryogenesis and early development resulted in macroscopically and microscopically detectable phenotypic changes, including kink tail, sparse fur coat and enlarged sebaceous glands. [Dev Biol] Abstract


HEDGEHOG/GLI-E2F1 Axis Modulates IASPP Expression and Function and Regulates Melanoma Cell Growth
The authors presented evidence that both GLI1 and GLI2, the final effectors of hedgehog signaling, regulate the transcription factor E2F1 in melanoma cells, by binding to a functional non-canonical GLI consensus sequence. [Cell Death Dis] Full Article

Twist1 Regulates Keratinocyte Proliferation and Skin Tumor Promotion
Researchers evaluated the effect of deleting Twist1 on keratinocyte proliferation and on skin tumor development using the two-stage chemical carcinogenesis model. [Mol Carcinog] Abstract

Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice
Scientists suggested that a prolonged exposure to space conditions may induce skin atrophy, deregulate hair follicle cycle, and markedly affect the transcriptomic repertoire of the cutaneous striated muscle panniculus carnosus. [NPJ Microgravity] Full Article

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Molecular Architecture and Function of the Hemidesmosome
The authors review the molecular characteristics of the proteins that make up the hemidesmosome core structure and summarize the current knowledge about how their assembly and turnover are regulated by transcriptional and post-translational mechanisms. [Cell Tissue Res] Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Ludwig Scientists to Report Advances in Treatment of Brain, Skin, Gastrointestinal Cancers
Ludwig researchers will present recent data from early and late stage clinical trials and participate in a number of plenary and educational sessions. [Press release from Ludwig Cancer Research discussing research to be presented at the 2015 American Society for Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

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Turning Cancer Against Itself: Major Grant Advances Pioneering Melanoma Therapy at NeoStem
NeoStem, Inc. announced that it will receive one of the largest research grants of its kind to support its pioneering treatment for patients with stage III recurrent or stage IV metastatic melanoma. [NeoStem, Inc.] Press Release

Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 11th International Congress on Systemic Lupus Erythematosus 2015
September 2-6, 2015
Vienna, Austria

Visit our events page to see a complete list of events in the dermal cell community.
NEW Postdoctoral Fellow – Computational Biology and Bioinformatics in Melanoma (Icahn School of Medicine at Mount Sinai)

NEW Postdoctoral Fellow – Stem Cell Niche Function (Icahn School of Medicine at Mount Sinai)

Assistant Professor – Dermatology (University of California, Davis)

Dermatology Specialty Representative (Celgene Corporation)

Assistant Professor – Instructive Biomaterials Engineering (Maastricht University)

Professor – Dermatology (University of Wisconsin – Madison)

Chair of the Department of Dermatology (University of California, Davis)

Faculty Positions – Stem Cell & Regenerative Medicine (University of Texas Medical School at Houston)

Postdoctoral Positions – Molecular Cancer Biology (University of Pennsylvania)

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