Volume 2.14 | Apr 18

Dermal Cell News 2.14 April 18, 2016
Dermal Cell News
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Signaling Couples Hair Follicle Stem Cell Quiescence with Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis
Researchers found histone H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells (HFSCs) during G0 quiescence. The level of marks over specific gene promoters did not correlate to mRNA level changes in quiescent HFSCs. [Nat Commun] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin
To analyze the function of fibroblast-derived MMP-14 in adult skin homeostasis investigators generated mice with inducible deletion of MMP-14 in the dermal fibroblast. [J Invest Dermatol] Abstract

A Novel Plant Sesquiterpene Lactone Derivative DETD-35 Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice
Investigators created a novel semi-organically modified derivative, DETD-35, from deoxyelephantopin, a plant sesquiterpene lactone demonstrated as an anti-inflammatory and anti-mammary tumor agent. Their results showed that DETD-35 inhibited proliferation of a panel of melanoma cell lines. [Mol Cancer Ther]
Abstract | Full Article

Controlled Water Vapor Transmission Rate Promotes Wound-Healing via Wound Re-Epithelialization and Contraction Enhancement
Researchers prepared serial polyurethane membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. The dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. [Sci Rep] Full Article

Cellularized Bilayer Pullulan-Gelatin Hydrogel for Skin Regeneration
By combining two polymers: pullulan, an inexpensive polysaccharide with antioxidant properties, and gelatin, a derivative of collagen with high water absorbency, investigators created a novel inexpensive hydrogel-named PG-1 for “pullulan-gelatin first generation hydrogel”-suitable for skin substitutes. [Tissue Eng Part A] Abstract

Downregulation of YAP-Dependent Nupr1 Promotes Tumor-Repopulating Cell Growth in Soft Matrices
The authors showed that nuclear protein 1 (Nupr1), a protein independent of Sox2, is downregulated in tumor-repopulating cells of melanoma, ovarian cancer and breast cancer cultured in soft fibrin matrices. [Oncogenesis] Full Article

Gelatin/Carboxymethyl Chitosan Based Scaffolds for Dermal Tissue Engineering Applications
Scientists delineated the preparation, characterization and application of gelatin-carboxymethyl chitosan scaffolds for dermal tissue engineering. [Int J Biol Macromol] Abstract


Standard Melanoma-Associated Markers Do Not Identify the MM127 Metastatic Melanoma Cell Line
Common markers used to identify melanoma cell lines include: S100; HMB-45; and Melan-A. Investigators explored the expression of these three markers in four different melanoma cell lines: WM35; WM793; SK-MEL-28; and MM127. [Sci Rep] Full Article

Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes
To investigate the function of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in keratinocytes during inflammation in vivo, researchers created keratinocyte-specific 11β-HSD1 knockout mice and analyzed the inflammatory response in models of hapten-induced contact irritant dermatitis. [Am J Pathol] Abstract

Cross-Talk between DopaChromeTautomerase and Caveolin-1 Is Melanoma Cell Phenotype Specific and Potentially Involved in Tumor Progression
A structural and functional relationship between dopachrometautomerase and caveolin-1 was presented in two human amelanotic melanoma cell lines, derived from vertical growth phase and metastatic melanomas. [J Biol Chem] Abstract | Full Article

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Wound Repair: A Showcase for Cell Plasticity and Migration
A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease. [Curr Opin Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
University of Pennsylvania to Join First-of-Its-Kind Research Collaboration to Fight Cancer with New Immunotherapies
The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six of the nation’s top medical schools and cancer centers around a shared aim of accelerating breakthrough immunotherapy research that will turn more cancers into a curable disease. The venture is backed by a $250 million gift from the Parker Foundation, making it the largest single contribution ever made to the field of immunotherapy. [University of Pennsylvania] Press Release

UCLA Joins Collaboration to Advance Cancer Immunotherapy Research
UCLA has joined forces with five of the nation’s other leading cancer centers and The Parker Institute for Cancer Immunotherapy to maximize the potential of cancer immunotherapy research. [UCLA] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Signaling in Cancer: From Mechanisms to Therapy
June 5-10, 2016
Snowmass Village, United States

Visit our events page to see a complete list of events in the dermal cell community.
NEW Postdoctoral Scientist – Molecular Oncology Group (Cancer Research UK Manchester Institute)

Faculty Position – Tumor Immunology (John Wayne Cancer Institute at Providence Saint John’s Health Center)

Postdoctoral Position – Stem Cell Biology and Tissue Engineering (Northeastern University)

Skincare Applied Research Manager (L’Oreal)

Senior Bioinformatician – Cutaneous Medicine (Guy’s & St. Thomas’ NHS Foundation Trust)

Postdoctoral Research Fellow – Cancer and Inflammatory Diseases of the Skin (Weill Cornell Medical College)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

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