Cellularized Bilayer Pullulan-Gelatin Hydrogel for Skin Regeneration
By combining two polymers: pullulan, an inexpensive polysaccharide with antioxidant properties, and gelatin, a derivative of collagen with high water absorbency, investigators created a novel inexpensive hydrogel-named PG-1 for “pullulan-gelatin first generation hydrogel”-suitable for skin substitutes. [Tissue Eng Part A] Abstract
Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes
To investigate the function of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in keratinocytes during inflammation in vivo, researchers created keratinocyte-specific 11β-HSD1 knockout mice and analyzed the inflammatory response in models of hapten-induced contact irritant dermatitis. [Am J Pathol] Abstract
Wound Repair: A Showcase for Cell Plasticity and Migration
A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease. [Curr Opin Cell Biol] Abstract
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INDUSTRY NEWS
University of Pennsylvania to Join First-of-Its-Kind Research Collaboration to Fight Cancer with New Immunotherapies
The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six of the nation’s top medical schools and cancer centers around a shared aim of accelerating breakthrough immunotherapy research that will turn more cancers into a curable disease. The venture is backed by a $250 million gift from the Parker Foundation, making it the largest single contribution ever made to the field of immunotherapy. [University of Pennsylvania] Press Release
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