Volume 2.10 | Mar 21

Dermal Cell News 2.10 March 21, 2016
Dermal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Study Identifies Factors That Shape How Advanced Melanoma Responds to Immunotherapy
Researchers revealed how patterns of gene mutations and expression in a melanoma tumor before starting anti-PD-1 immunotherapy may forecast whether the tumor would shrink or the patient would derive survival benefits. [Press release from University of California, Los Angeles discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract
Watch Video MesenTrek Rise of Enriched Mouse MSC Cultures
 
PUBLICATIONS (Ranked by impact factor of the journal)
DERMAL STEM CELLS & TISSUE REGENERATION

Cellular Forces and Matrix Assembly Coordinate Fibrous Tissue Repair
The authors developed a 3D biomimetic model for soft tissue repair and demonstrated that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24 hours. [Nat Commun] Full Article

Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles
Investigators used six transgenic reporters to isolate 14 major skin and hair follicle cell populations. With next-generation RNA sequencing, they characterized their transcriptomes and defined unique molecular signatures. [Cell Rep] Full Article | Graphical Abstract

Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis
The authors showed that YAP and TAZ are nuclear localized in the basal layer of skin and are elevated upon wound healing. Skin-specific deletion of both YAP and TAZ in adult mice slows proliferation of basal layer cells, leads to hair loss and impairs regeneration after wounding. [Development] Abstract

The Parkinsonism-Associated Protein DJ-1/Park7 Prevents Glycation Damage In Human Keratinocyte
The authors investigated the ability of DJ-1 to prevent protein glycation in keratinocytes. Glycation of collagen and keratinocyte proteins was tested by measuring ultraviolet absorption and fluorescence emission. [Biochem Biophys Res Commun] Abstract

SKIN CANCERS & DISORDERS

Directed Migration of Cancer Cells by the Graded Texture of the Underlying Matrix
Researchers report a new type of directed migration—which they term ‘topotaxis’—guided by the gradient of the nanoscale topographic features in the cells’ extracellular matrix environment. [Nat Mater]
Abstract | Press Release

Inhibiting Drivers of Non-Mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy
Investigators examined the therapy phase before acquired resistance had developed and discovered the melanoma survival oncogene MITF as a driver of an early non-mutational and reversible drug-tolerance state, which is induced by PAX3-mediated upregulation of MITF. [Cancer Res]
Abstract | Graphical Abstract | Press Release

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2 Triggered Drug Resistance
Investigators report on the impact of class I histone deacetylase (HDAC) on the response of malignant melanoma cells treated with alkylating agents. The data showed that malignant melanomas in situ contain a high level of HDAC1/2 and malignant melanoma cells overexpress HDAC1/2/3 compared to non-cancer cells. [Cancer Cell] Abstract

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Scientists documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stages, and that phospho-FAK and BRAF are HSP70 client proteins. [Cancer Res] Abstract

Learn More: Standardized Tools for Cancer Research
 
REVIEWS
Pericytes: A Newly Recognized Player in Wound Healing
The authors discuss pericyte involvement in wound repair and the relationship pericytes form with the parenchymal cells of the skin. [Wound Repair Regen] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
 
INDUSTRY NEWS
Baylor College of Medicine, Baylor Scott & White Health Announce Collaboration on Biomedical Research
Baylor College of Medicine and Baylor Scott & White Health have entered into an agreement to expand biomedical research in North and Central Texas. [Baylor Scott & White Health] Press Release

Provectus Biopharmaceuticals Amends Protocol for Phase III Study of PV-10 in Treatment of Locally Advanced Cutaneous Melanoma
Provectus Biopharmaceuticals, Inc. announced that the protocol for its Phase III clinical trial for PV-10 as an investigational treatment for melanoma has been amended to reflect current and evolving standards of care and applicable patient population for a global study in melanoma. [Provectus Biopharmaceuticals, Inc.] Press Release

SRI International Receives $19.8 Million National Cancer Institute Contract for PREVENT Cancer Program
SRI International has been awarded a contract of up to $19.8 million from the National Cancer Institute PREVENT Cancer Preclinical Drug Development Program to support the development of potential cancer preventive agents or vaccines. [SRI International] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the dermal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Senior Postdoctoral Researcher – Uveal Melanoma (Institut Curie)

Postdoctoral Researcher – Skin Biology and Mitochondria (Karolinska Institutet)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Faculty Position – Melanoma and Immunotherapy (Weill Cornell College of Medicine)

Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)


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