Volume 2.07 | Feb 29

Dermal Cell News 2.07 February 29, 2016
Dermal Cell News
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Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts
The authors demonstrated that normal dermal fibroblasts expressing high pigment epithelium-derived factor (PEDF) levels attenuated melanoma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects. [Cancer Res] Abstract
Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
PUBLICATIONS (Ranked by impact factor of the journal)

Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age
The authors previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. They hypothesized that these differences in culture success were related to epigenetic differences between the cultured fibroblasts by sampling location, and therefore generated genome-wide DNA methylation and transcriptome data on 11 intrinsically matched pairs of dural and scalp fibroblasts from donors across the lifespan. [PLoS Genet] Full Article | Press Release

Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-Wound Bandages
Anti-microbial polycationic dendrimers G3KL and G3RL, able to kill multi-drug resistant Pseudomonas aeruginosa, have been previously developed. The combination of these dendrimers with a class of biological bandages made of progenitor skin cells, which secrete growth factors, could positively impact wound-healing processes. [Sci Rep] Full Article | Press Release

Glycerolized Reticular Dermis as a New Human Acellular Dermal Matrix: An Exploratory Study
Scientists aimed to develop a new type of human acellular dermal matrix for clinical use, composed of glycerolized reticular dermis decellularized through incubation and tilting in Dulbecco’s Modified Eagle’s Medium. [PLoS One] Full Article


DNMT3B Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
Scientists report that DNMT3B plays a pro-tumorigenic role in human melanoma and that DNMT3B loss dramatically suppresses melanoma formation in the Braf/Pten mouse melanoma model. [Cell Rep]
Full Article | Graphical Abstract | Press Release

Melatonin Protects Skin Keratinocyte from Hydrogen Peroxide-Mediated Cell Death via the SIRT1 Pathway
The authors investigated the protection effect of melatonin on H2O2-induced cell damage and the mechanisms of melatonin in human keratinocytes. [Oncotarget] Full Article

Ultraviolet Radiation-Induced Tumor Necrosis Factor Alpha, Which Is Linked to the Development of Cutaneous SCC, Modulates Differential Epidermal MicroRNAs Expression
To find clues about the mechanisms by which tumor necrosis factor-alpha may promote ultraviolet radiation-induced development of squamous cell carcinoma (SCC), researchers investigated changes in the expression profiling of microRNAs, which affects translation and stability of mRNAs. [Oncotarget] Full Article

Transketolase-Like 1 Ectopic Expression Is Associated with DNA Hypomethylation and Induces the Warburg Effect in Melanoma Cells
Investigators evaluated the role of transketolase-like 1 as a mediator of disease progression in melanoma associated with a defective methylation phenotype. [BMC Cancer] Full Article

Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes
Investigators report global changes in histone post-translational modifications induced by solar simulated ultraviolet radiation (ssUVR). A decrease in lysine acetylation of histones H3 and H4, particularly at positions of H3 lysine 9, lysine 56, H4 lysine 5, and lysine 16, was found in human keratinocytes exposed to ssUVR. [PLoS One] Full Article

Learn More: Standardized Tools for Cancer Research
Histone Variants and Melanoma: Facts and Hypotheses
The authors focus on the role of histone variants, key epigenetic players in melanoma initiation and progression. Specifically, incorporation of histone variants enables additional layers of chromatin structure and they describe how alterations in this epigenetic behavior impact melanoma. [Pigment Cell Melanoma Res] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
Lilly Receives Positive CHMP Opinion for Ixekizumab for the Treatment of Moderate-to-Severe Plaque Psoriasis
Eli Lilly and Company announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive opinion for ixekizumab for the treatment of moderate-to-severe plaque psoriasis in adults in the European Union who are candidates for systemic therapy. [Eli Lilly and Company] Press Release

Roswell Park Teams Awarded Nearly $7 Million in Research Funding
Investigators at Roswell Park Cancer Institute have garnered nearly $7 million in recent research grants. The awards include a five-year, $2.4 million grant from the National Cancer Institute to optimize a particular approach for administering photodynamic therapy. [Roswell Park Cancer Institute] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 24th Biennial European Association for Cancer Research (EACR) Congress
July 9-16, 2016
Manchester, United Kingdom

Visit our events page to see a complete list of events in the dermal cell community.
NEW Assistant Professor – Regenerative Medicine (Ming Wai Lau Center for Regenerative Medicine)

NEW PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Postdoctoral Position – Computational Biology of Inflammatory Skin Diseases (Helmholtz Association)

Faculty Position – Melanoma and Immunotherapy (Weill Cornell College of Medicine)

Postdoctoral Position – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

Postdoctoral Research Scientist – Skin Wound Healing and Inflammation (Inserm)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

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