Volume 2.04 | Feb 1

Dermal Cell News 2.04 February 1, 2016
Dermal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization
Scientists revealed that BRAF-CRAF complex formation is significantly associated with BRAF inhibitor (BRAFi) treatment and may therefore serve as a useful biomarker of BRAFi-induced cutaneous and extracutaneous tumor formation. [Cancer Res] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
DERMAL STEM CELLS & TISSUE REGENERATION

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair
Investigators unraveled the function of glutathione in keratinocytes and its cross-talk with other antioxidant defense systems. [PLoS Genet] Full Article

Fractionation of a Tumor-Initiating UV Dose Introduces DNA Damage-Retaining Cells in Hairless Mouse Skin and Renders Subsequent TPA-Promoted Tumors Non-Regressing
Researchers focus on a possible difference in tumor initiation from a single severe-sunburn dose and from an equal dose fractionated into very low sub-sunburn doses not causing any (growth-promoting) epidermal hyperplasia. [Oncotarget] Full Article

Generation of Skin Tissue Using Adipose Tissue-Derived Stem Cells
The authors generated skin tissue using adipose tissue-derived mesenchymal stem cells. [Plast Reconstr Surg] Full Article

Effects of UVB Radiation on the Physicochemical Properties of Fibroblasts and Keratinocytes
Scientists determined the influence of short-wave ultraviolet (UVB) radiation on the membrane electrical properties, phospholipid content, and lipid peroxidation levels of fibroblasts and keratinocytes. [J Membr Biol] Abstract

Topical Application of Epidermal Growth Factor with No Scaffold Material on the Healing of Human Traumatic Tympanic Membrane Perforations
Investigators evaluated the effects of conservative treatment and topical application of epidermal growth factor with no scaffold material on the healing of human traumatic tympanic membrane perforations. [Clin Otolaryngol] Abstract

SKIN CANCERS & DISORDERS

FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells
Using an experimental metastasis model, scientists discovered that high levels of the WNT receptor, FZD7, correlated with enhanced metastatic potentials of melanoma cell lines. [PLoS One] Full Article

A Novel Multi-CDK Inhibitor P1446A-05 Restricts Melanoma Growth and Produces Synergistic Effects in Combination with MAPK Pathway Inhibitors
Scientists report that P1446A-05, a novel multi-CDK inhibitor has significant inhibitory activity against cutaneous and uveal melanoma. [Cancer Biol Ther] Abstract

MiR-217 Is Down-Regulated in Psoriasis and Promotes Keratinocyte Differentiation via Targeting GRHL2
The authors found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of psoriatic patients. [Biochem Biophys Res Commun] Abstract

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REVIEWS
MicroRNAs in Psoriasis
The authors present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis. [J Invest Dermatol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
 
INDUSTRY NEWS
Valeant Announces FDA Acceptance of BLA Submission for Brodalumab in Moderate-to-Severe Plaque Psoriasis
Valeant Pharmaceuticals International, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted for review the biologics license application submitted by AstraZeneca in partnership with Valeant, for brodalumab injection, a monoclonal antibody that targets the IL-17 receptor, in development for patients with moderate-to-severe plaque psoriasis. [Valeant Pharmaceuticals International, Inc.] Press Release

Rockland Immunochemicals, Inc. Introduces Melanoma Cell Lines in Collaboration with The Wistar Institute
Rockland Immunochemicals, Inc. announced the availability of a new collection of human melanoma cell lines that have been developed and characterized over several decades in the laboratory of Meenhard Herlyn, D.V.M., D.Sc., Caspar Wistar Professor in Melanoma Research, Director of the Melanoma Research Center, and professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute in Philadelphia. [Rockland Immunochemicals, Inc.] Press Release

DDK 60 Million Awarded for Four Interdisciplinary Research Projects
The Novo Nordisk Foundation has awarded grants for four interdisciplinary research projects under the Interdisciplinary Synergy Program. Each project receives up to DKK 15 million per year for three years. [Novo Nordisk Foundation] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ISSCR 2016 Annual Meeting
June 22-25, 2016
San Francisco, United States

Visit our events page to see a complete list of events in the dermal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

Professor – Dermatology (Eberhard Karls Universität Tübingen)

Postdoctoral Research Scientist – Skin Wound Healing and Inflammation (Inserm)

Postdoctoral Fellow – Skin Cancer (German Cancer Research Center)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Professor – Dermato-oncology (Rheinische Friedrich-Wilhelms-University of Bonn)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Position – Regenerative Medicine (University of Copenhagen)

Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

Research Fellow – Dermatology (Brigham and Women’s Hospital)


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