Volume 1.28 | Dec 14

Dermal Cell News 1.28 December 14, 2015
Dermal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Transcription Factor ATF2 Promotes Melanoma Metastasis by Suppressing Protein Fucosylation
The authors found that protein kinase Cε (PKCε)–mediated activation of activating transcription factor 2 (ATF2) controls the migratory and invasive behaviors of melanoma cells. In primary melanocytes and cell lines representing early-stage melanoma, the abundance of PKCε-phosphorylated ATF2 was low, thereby enabling the expression of FUK and cellular protein fucosylation, which promoted cellular adhesion and reduced motility. [Sci Signal] Abstract
Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
 
PUBLICATIONS (Ranked by impact factor of the journal)
DERMAL STEM CELLS & TISSUE REGENERATION

A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians
RNA sequencing on 619 single cells revealed that wound-induced genes were expressed either in nearly all cell types or specifically in one of three cell types (stem cells, muscle, or epidermis). Time course experiments following different injuries indicated that a generic wound response is activated with any injury regardless of the regenerative outcome. [Dev Cell] Full Article

Ex Vivo Multiscale Quantitation of Skin Biomechanics in Wild-Type and Genetically-Modified Mice Using Multiphoton Microscopy
To investigate the relationship between the microstructure of normal and diseased skins and their macroscopic mechanical properties, the authors imaged and quantified the microstructure of dermis of ex vivo murine skin biopsies during uniaxial mechanical assay using multiphoton microscopy. [Sci Rep] Full Article

Topical Treatment with Coenzyme Q10-Containing Formulas Improves Skin’s Q10 Level and Provides Antioxidative Effects
Investigators showed that topical ubiquinone (Q10) treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. [Biofactors] Abstract

Intradermal Injection of Human Adipose-Derived Stem Cells Accelerates Skin Wound Healing in Nude Mice
Scientists evaluated the potential effect of adipose-derived stem cells on the healing of 12 mm diameter-excisional wounds in nude mice. [Stem Cell Res Ther] Full Article

On-Chip Assay of the Effect of Topographical Microenvironment on Cell Growth and Cell-Cell Interactions during Wound Healing
The authors designed a wound healing device to recapitulate in vivo complex microenvironments and heterogeneous cell situations to investigate how three types of physiologically related cells interact with their microenvironments around and with each other during a wound healing process. [Biomicrofluidics] Abstract

SKIN CANCERS & DISORDERS

Phloretin Increases the Anti-Tumor Efficacy of Intratumorally Delivered Heat-Shock Protein 70 kDa (HSP70) in a Murine Model of Melanoma
Investigators studied the effect of the combination of HSP70 and phloretin using B16 melanoma and a novel method of HSP70-gel application. They found that the addition of phloretin to the gel reduced tumor weight almost five-fold compared with untreated mice, while the life span of the animals extended from 25 to 39 days. [Cancer Immunol Immunother] Abstract

Investigation of FOXM1 as a Potential New Target for Melanoma
Scientists investigated the forkhead box M1 (FOXM1) expression in human melanoma samples and cell lines, to evaluate the relationship between FOXM1 expression and the clinical features of melanoma patients and to investigate the association between the FOXM1 and MAPK and PI3K/AKT pathways in melanoma cell lines. [PLoS One] Full Article

Opposing Effects of Zac1 and Curcumin on AP-1-Regulated Expressions of S100A7
Researchers demonstrated that mZac1 can enhance AP-1-responsive S100A7 expression of which the encoding gene was located in PSORS4 with HaCaT keratinocytes. [PLoS One] Full Article

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REVIEWS
Secukinumab (AIN-457) for the Treatment of Psoriasis
The authors address the rationale for targeting the IL-23/Th17/IL-17 axis, the role of IL-17 and Th17 cells in psoriasis and other chronic inflammatory diseases, and will examine pre-clinical studies, pharmacologic properties, clinical efficacy, and the safety profile of secukinumab. [Expert Rev Clin Pharmacol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
 
INDUSTRY NEWS
Cipher Receives Health Canada Approval of PRBeteflam™
Cipher Pharmaceuticals Inc. announced that Health Canada has approved PrBeteflam™, a novel, patent-protected treatment of mild to moderate plaque psoriasis of the elbows and knees for a maximum duration of 30 days in adult patients. [Cipher Pharmaceuticals Inc.] Press Release

Idera Phamaceuticals Announces Initiation of Phase I/II Clinical Trial of Intra-Tumoral IMO-2125 in Combination with Ipulimumab in Patients with Metastatic Melanoma
Idera Pharmaceuticals, Inc. announced that the company has commenced enrollment in a Phase I/II clinical trial evaluating intra-tumoral IMO-2125, a TLR9 agonist in combination with ipilimumab in patients with previously treated metastatic melanoma. [Idera Pharmaceuticals, Inc.] Press Release

Nektar Announces First Patient Dosed in Phase I/II Clinical Study of NKTR-214, a CD122-Biased Immuno-Stimulatory Cytokine
Nektar Therapeutics announced that dosing has commenced in the Phase I/II clinical study evaluating the efficacy and safety of NKTR-214 in the treatment of solid tumors. NKTR-214 is a novel CD122-biased cytokine designed to preferentially activate the beta and gamma sub-units of the IL-2 receptor in order to proliferate tumor-killing T cells within the body without stimulating regulatory T cells. [Nektar Therapeutics] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW German Cancer Congress 2016
February 24-27, 2016
Berlin, Germany

Visit our events page to see a complete list of events in the dermal cell community.
 
JOB OPPORTUNITIES
NEW Research Fellow – Dermatology (Brigham and Women’s Hospital)

Professor – Dermatology (Universität Tübingen)

Group Leader Position – Cancer Research (Oslo University Hospital)

Postdoctoral Position – Molecular Cancer Biology (University of Pennsylvania)

PhD Position – Cancer Research and Wound Healing (Technion, Israel Institute of Technology)

Research Associate/Scientist – Dermato-Pharmacokinetics (Simcyp)

Senior Manager – Immunology (Baxalta Innovations GmbH)

Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)


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