Transient PLK4 Overexpression Accelerates Tumorigenesis in p53-Deficient Epidermis

Dermal Cell News 1.25 November 23, 2015

TOP STORY

Transient PLK4 Overexpression Accelerates Tumorigenesis in p53-Deficient Epidermis
Using Plk4 overexpression during epidermal development, researchers assessed the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis. [Nat Cell Biol] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Aberrant Notch Signaling Contributes to Hypertrophic Scar Formation by Modulating the Phenotype of Keratinocytes
Researchers found that Notch1, Notch intracellular domain, Jagged1, and Hes-1 were overexpressed in the epidermis of patients with hypertrophic scar. [Exp Dermatol] Abstract

PHF11 Expression and Cellular Distribution Is Regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT Keratinocytes
In addition to a role for PHF11 in lymphocyte gene expression, investigators showed that PHF11 was part of the keratinocyte innate immune response by poly(I:C). [BMC Immunol] Full Article

Fibroblast-Loaded Cholecyst-Derived Scaffold Induces Faster Healing of Full Thickness Burn Wound in Rabbit
Scientists examined the use of a cholecyst scaffold for preparing bio-artificial grafts by loading homologous fibroblasts. The healing potential was evaluated in a rabbit model of full thickness skin-burn wound. [J Biomater Appl] Abstract

Anti-Wrinkle Effects of a Tuna Heart H₂O Fraction on Hs27 Human Fibroblasts
The authors examined the anti-wrinkle effects of tuna heart extract which are mediated through the inhibition of matrix metalloproteinases in skin cells. [Int J Mol Med] Abstract | Download Full Article

SKIN CANCERS & DISORDERS

MicroRNA-3151 Inactivates TP53 in BRAF-Mutated Human Malignancies
Researchers showed that B-Raf proto-oncogene serine/threonine kinase (BRAF) mutations in both malignant melanoma and papillary thyroid cancer drive increased expression of oncomiR-3151, which is coactivated by the SP1/NF-κB complex. [Proc Natl Acad Sci USA] Abstract

ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas
By in vivo super-enhancer and transcriptional profiling, the authors uncovered a dynamic cancer-specific epigenetic network selectively enriched for binding motifs of a transcription factor cohort expressed in squamous cell carcinoma stem cells. [Elife] Abstract | Full Article

Encorafenib (LGX818), a Potent BRAF Inhibitor, Induces Senescence Accompanied by Autophagy in BRAFV600E Melanoma Cells
Scientists showed that LGX818 potently decreased ERK phosphorylation and inhibited proliferation in BRAFV600E melanoma cell lines. [Cancer Lett] Abstract

Long Non-Coding RNA TSIX Is Up-Regulated in Scleroderma Dermal Fibroblasts and Controls Collagen mRNA Stabilization
Researchers found TSIX was overexpressed in systemic sclerosis dermal fibroblasts both in vivo and in vitro, which was inhibited by the transfection of transforming growth factor-β1 siRNA. [Exp Dermatol] Abstract

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REVIEWS

Peculiarities and Pitfalls of Quantifying Mitochondrial Energy Metabolism in the Skin
The role of mitochondrial energy metabolism in healthy and diseased skin has become a hot topic in dermatology. For example, classic skin disorders affecting intermediate filaments such as epidermolysis bullosa can now be linked to mitochondrial pathophysiology. [Exp Dermatol] Abstract

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SCIENCE NEWS

Samumed to Announce Clinical Data on Potential Treatment of Androgenetic Alopecia
Samumed, LLC, a leader in tissue regeneration, announced that it will present clinical data on a small molecule (SM04554) for potential treatment of androgenetic alopecia. [Press release from Samumed, LLC discussing research presented at the 9^th World Congress for Hair Research (WCHR), Miami] Press Release

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INDUSTRY NEWS

Dermira Completes Patient Enrollment for Second CIMZIA^® (Certolizumab Pegol) Phase III Clinical Trial in Psoriasis Program
Dermira, Inc. announced the completion of patient enrollment for the global CIMPASI-1 clinical trial of CIMZIA^® (certolizumab pegol) in adult patients with moderate-to-severe chronic plaque psoriasis. [Dermira, Inc.] Press Release

MD Anderson Receives $22.2 Million in CPRIT Research Funding
The University of Texas MD Anderson Cancer Center was awarded more than $22 million in research grants from the Cancer Prevention and Research Institute of Texas (CPRIT). MD Anderson CPRIT awards included $14.8 million for research, $6 million in recruitment funding and $1.4 million for evidence-based cancer prevention services. [The University of Texas MD Anderson Cancer Center] Press Release

POLICY NEWS

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EVENTS

NEW 28^th Lorne Cancer Conference
February 11-13, 2016
Lorne, Australia

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JOB OPPORTUNITIES

NEW Research Associate/Scientist – Dermato-Pharmacokinetics (Simcyp)

Senior Manager – Immunology (Baxalta Innovations GmbH)

Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

Computational Biologist – UV Irradiation and Melanoma (Cancer Research UK Manchester Institute)

Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)

Postdoctoral Associate – Dermatology (University of Pittsburgh)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Medicinal Chemistry (Auburn University)

Independent Junior Group Leader – Human Genetics of Inflammatory Skin Diseases (University of Lübeck)

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