Volume 1.22 | Nov 2

Dermal Cell News 1.22 November 2, 2015
Dermal Cell News
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Recurrent Inactivating RASA2 Mutations in Melanoma
Scientists identifed RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. [Nat Genet] Full Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)

Gene Expression Profiling Reveals the Role of RIG1 Like Receptor Signaling in p53 Dependent Apoptosis Induced by PUVA in Keratinocytes
To study in detail the molecular mechanism of UVA radiation (PUVA) in keratinocytes, scientists investigated the genome wide transcriptomic changes using Illumina whole genome gene expression beadchip. They demonstrated that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the retinoic acid inducible gene-I (RIG-I) in a p53 and NFκB dependent manner. [Cell Signal] Abstract

Alocasia denudata Engler Treatment Enhance Open Wound Healing Activities in Wistar Rat’s Skin
The authors determined A. denudata treatment effects on open wound healing activities in Wistar rat’s skin. They showed that wounds treated with A. denudata stem juice possess a significantly higher rate of wound contraction, total protein concentration, hexosamine concentration and uronic acid concentration. [J Ethnopharmacol] Abstract

Methotrexate Normalized Keratinocyte Activation Cycle by Overturning Abnormal Keratins as Well as Deregulated Inflammatory Mediators in Psoriatic Patients
Researchers found the pharmacological effect of methotrexate on abnormal keratin and deregulated inflammatory mediators. [Clin Chim Acta] Abstract

Ibuprofen Loaded PLA Nanofibrous Scaffolds Increase Proliferation of Human Skin Cells In Vitro and Promote Healing of Full Thickness Incision Wounds In Vivo
In vitro cytotoxicity to human epidermal keratinocytes and human dermal fibroblasts of the three scaffolds with varying ibuprofen concentrations were evaluated and compared to pure polylactic acid (PLA) nanofibrous scaffolds. [J Biomed Mater Res B Appl Biomater] Abstract


Evolution of Metastasis Revealed by Mutational Landscapes of Chemically Induced Skin Cancers
Investigators used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous mice to demonstrate that most metastases disseminate synchronously from the primary tumor, supporting parallel rather than linear evolution as the predominant model of metastasis. [Nat Med] Abstract

The Homeoprotein DLX3 and Tumor Suppressor p53 Co-Regulate Cell Cycle Progression and Squamous Tumor Growth
The authors report on a novel DLX3-dependent network that constrains epidermal hyperplasia and squamous tumorigenesis. [Oncogene] Abstract

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination
The authors found that amoeboid melanoma cells are enriched in a transforming growth factor β (TGFβ)-driven signature. They observed that downstream of TGF-β, SMAD2 and its adaptor CITED1 control amoeboid behavior by regulating the expression of key genes that activate contractile forces. [Curr Biol]
Full Article | Graphical Abstract

Transcription Factor LSF (TFCP2) Inhibits Melanoma Growth
Researchers found decreased expression level of late SV40 factor 3 in skin melanoma compared to that in benign melanocytic tumors and nevi in mice and humans. [Oncotarget] Full Article

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A Novel Actor in Skin Biology: The Mineralocorticoid Receptor
The glucocorticoid receptor is a modulator of skin homeostasis, and local application of glucocorticoids is common in dermatology. In addition to their beneficial effects, glucocorticoids may induce deleterious side effects such as skin atrophy and delayed wound healing. [Exp Dermatol] Abstract

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Radiotherapeutic Bandage Shows Potential as Treatment for Skin Cancer
A radiotherapeutic bandage is being evaluated by researchers for efficacy against squamous cell carcinoma in an animal model. These results could confirm the viability of a new and improved strategy for the radiotherapeutic treatment of skin cancer in the clinic. [Press release from University of North Texas System College of Pharmacy discussing research presented at the American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Orlando] Press Release

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FDA Approves First-Of-Its-Kind Product for the Treatment of Melanoma
The U.S. Food and Drug Administration (FDA) approved Imlygic, the first FDA-approved oncolytic virus therapy, for the treatment of melanoma lesions in the skin and lymph nodes. [U.S. Food and Drug Administration] Press Release

Phase Holographic Imaging and University of California, San Francisco Commence Collaboration on Skin Cancer Research
University of California, San Francisco and Phase Holographic Imaging (PHI) have begun their collaboration agreement to accelerate on-going skin cancer research utilizing PHI’s proprietary label-free holographic imaging cytometry technology. [Phase Holographic Imaging (PR Newswire LLC.)] Press Release

Agena Bioscience and Diatech Pharmacogenetics Announce Plan to Launch Actionable, Targeted CE-IVD Marked Oncology Assays for Colon, Lung, and Melanoma Treatment
Agena Bioscience announced the planned commercial launch of its CE-IVD marked MassARRAY® Dx PLUS assays for gene-specific mutation testing to aid in the selection of targeted therapy regimens. [Agena Bioscience (PR Newswire LLC.)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Cancer Immunotherapy: Immunity and Immunosuppression Meet Targeted Therapies
January 24-28, 2016
Vancouver, Canada

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NEW Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)

Postdoctoral Associate – Dermatology (University of Pittsburgh)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Medicinal Chemistry (Auburn University)

Independent Junior Group Leader – Human Genetics of Inflammatory Skin Diseases (University of Lübeck)

Postdoctoral Position – Cancer and Developmental Biology (University of California, Irvine)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Fellow – Cancer Genetics (Feinberg School of Medicine)

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