UCLA Researchers’ Discovery Is Milestone in Understanding Treatment-Resistant Melanoma
Scientists studied drug resistance by analyzing samples of patients’ melanoma tumors both before they underwent therapy and when the disease recurred. The scientists also replicated the process outside of the human body — modeling drug resistance by growing melanoma cell lines from patients’ tumors and adapting them to drugs that block the MAP kinase pathway. [Press release from UCLA discussing online publication in Cell] Press Release|Abstract|Graphical Abstract
The E3 Ligase Itch Knock-Out Mice Show Hyper-Proliferation and Wound Healing Alteration
Scientists investigated the contribution of Itch in skin development and wound healing. Itchy new born mice manifested hyperplastic epidermis, which is not present in adulthood. Itch-/- cultured keratinocytes showed over expression of proliferating markers, increased capability to proliferate, migrate and to repair a scratch injury in vitro. [FEBS J] Abstract
Maintenance of Sweat Glands by Stem Cells Located in the Acral Epithelium
Researchers identified the specific stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis and that facilitate the regeneration of these structures following injury. [Biochem Biophys Res Commun] Full Article
Absence of RIPK3 Predicts Necroptosis Resistance in Malignant Melanoma
Scientists investigated the impact of inhibitor of apoptosis (IAPs) proteins for cell death regulation in malignant melanoma. Suppression of IAPs strongly sensitized a panel of melanoma cells to death ligand-induced cell death, which was largely mediated by apoptosis, as it was completely rescued by addition of caspase inhibitors. [Cell Death Dis] Full Article
REVIEWS
The MAGE Protein Family and Cancer
The authors highlight recent developments into the function of melanoma antigen genes (MAGEs) as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field. [Curr Opin Cell Biol] Abstract
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INDUSTRY NEWS
Cancer Research UK and MedImmune Launch Ground-Breaking Biotherapeutics Research Center in Cambridge
A new laboratory that will focus on the discovery and development of novel biologic cancer treatments and diagnostics has been opened in Cambridge. The state-of-the-art CRUK-MEDI Alliance Laboratory is an innovative collaboration between Cancer Research UK, its commercial arm Cancer Research Technology, and MedImmune, the global biologics research and development arm of AstraZeneca. [Cancer Research UK] Press Release
UAMS Scientist Awarded $1.7 Million Grant for Melanoma Research
University of Arkansas for Medical Sciences (UAMS) researcher Vladimir Zharov, Ph.D., D.Sc., was awarded a $1.7 million grant by the National Cancer Institute for clinical testing of a new technology called Theranostics, which is an integration of early diagnosis and treatment of melanoma. [University of Arkansas for Medical Sciences] Press Release
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