Volume 1.00 | May 4

Dermal Cell News 1.00 May 4, 2015
Dermal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Schwann Cells Generated from Neonatal Skin-Derived Precursors or Neonatal Peripheral Nerve Improve Functional Recovery after Acute Transplantation into the Partially Injured Cervical Spinal Cord of the Rat
The authors previously demonstrated that delayed transplantation of Schwann cells (SCs) generated from neonatal mouse skin-derived precursors (SKP-SCs) promoted repair and functional recovery in rats with thoracic contusions. They conducted two experiments using neonatal rat cells and an incomplete cervical injury model to examine the efficacy of acute SKP-SC transplantation versus media control and versus nerve-derived SC or dermal fibroblast transplantation. [J Neurosci] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
DERMAL STEM CELLS & TISSUE REGENERATION

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells
Investigators developed lipid nanocarriers, called squarticles, conjugated with anti-platelet-derived growth factor-receptor β antibody to determine whether targeted Minoxidil delivery to the follicles and dermal papilla cells could be achieved. [Nanomedicine] Abstract

Activation and Regulation of the Granulation Tissue Derived Cells with Stemness-Related Properties
Granulation tissue derived cells (GTCs) were isolated and their in vitro proliferation, self-renewing, migration, and multi-differentiation capabilities were assessed. Combined radiation and a skin wound model were used to investigate the therapeutic effects of GTCs. [Stem Cell Res Ther] Full Article

Ultraviolet B (UVB) Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics
Researchers demonstrated that UVB can delay the wound healing progress in vivo with a murine model of full thickness skin wound. [Photochem Photobiol] Abstract

Adipose-Derived Stromal Cell Cluster with Light Therapy Enhance Angiogenesis and Skin Wound Healing in Mice
The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted cluster human adipose-derived mesenchymal stem cells (hASCs) in a skin wound animal model. The hASCs were cultured in monolayer or clusters. The LLLT, hASCs, hASC clusters, and hASC clusters transplantation with LLLT were applied to the wound bed in athymic mice. [Biochem Biophys Res Commun] Abstract

SKIN CANCERS & DISORDERS

Protein Tyrosine Kinase 6 Regulates UVB Induced Signaling and Tumorigenesis in Mouse Skin
The authors found that Protein Tyrosine Kinase 6 (PTK6) expression increases in the epidermis following UVB treatment. To evaluate the roles of PTK6 in the skin following UVB-induced damage, they exposed back skin of Ptk6+/+ and Ptk6-/- SENCAR mice to incremental doses of UVB for thirty weeks. [J Invest Dermatol] Abstract

Rho Kinase Inhibitor Fasudil Suppresses Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo
Scientists established an in vitro model of vasculogenic mimicry (VM) using 3-dimensional cell culturing of mouse B16 melanoma cells and studied VM in vivo by transplanting B16 mouse melanoma cells into C57/BL mice. [Mol Cancer Ther] Abstract

Evaluation of 68Ga- and 177Lu-DOTA-PEG4-LLP2A for VLA-4 Targeted PET Imaging and Treatment of Metastatic Melanoma
Researchers evaluated 177Lu- and 68Ga-labeled DOTA-PEG4-LLP2A as a very late antigen-4 (VLA-4) targeted radiotherapeutic with a companion PET agent for diagnosis and monitoring metastatic melanoma treatment. DOTA-PEG4-LLP2A was synthesized by solid phase synthesis. The affinity of 177Lu- and 68Ga-labeled DOTA-PEG4-LLP2A to VLA-4 was determined in B16F10 melanoma cells by saturation binding and competitive binding assays, respectively. [Mol Pharm] Abstract

Chemokine-Like Factor 1-Derived C-Terminal Peptides Induce the Proliferation of Dermal Microvascular Endothelial Cells in Psoriasis
To explore its role in the pathogenesis of psoriasis, the expression of both chemokine-like factor 1 (CKLF1) and its receptor (CCR4) was determined in psoriatic lesions. Also, the effect of the C-terminal peptides (C19 and C27) of CKLF1 on the proliferation of human umbilical vein endothelial cells was studied in vitro. [PLoS One] Full Article

Tissue Engineering Strategies as Tools for Personalized Meningioma Treatment
Researchers constructed cancer-like tissues to be used as tools for determining the most effective drug for an individual patient. Using tissue engineering strategies, they generated two different solid tumor-like tissues in vitro, a neuronal tumor (meningioma) and a nonmelanoma skin cancer. [Artif Organs] Abstract

Cryopreservation Media for Stem Cells - Learn More!
 
REVIEWS
Angiogenesis and Lymphangiogenesis in Inflammatory Skin Disorders
Angiogenesis, the growth of new blood vessels from pre-existing vessels, occurs physiologically in wound healing, during inflammatory diseases, and in tumor growth. Lymphangiogenesis can be activated in inflammation and tumor metastasis. The family of vascular endothelial growth factors and angiopoietins are essential for angiogenesis and lymphangiogenesis. [J Am Acad Dermatol] Abstract

Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin and Intestinal Stem Cell Compartments
Under stress conditions such as acute injury, the surprising developmental flexibility of blood, skin and intestinal epithelium stem cells enables them to adapt to diverse roles and to acquire different regeneration capabilities. This paradigm shift raises many new questions about the developmental origins, inter-relationships and molecular regulation of these multiple stem cell types. [Nat Rev Mol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.
 
SCIENCE NEWS
Derma Sciences to Present Clinical Data Demonstrating Efficacy in Tissue Regeneration at the Spring Symposium on Advanced Wound Care
Derma Sciences, Inc. presented 14 posters at the Spring Symposium on Advanced Wound Care (SAWC) in San Antonio, Texas this weekend. [Press release from Derma Sciences discussing research presented at the Spring Symposium on Advanced Wound Care, San Antonio] Press Release

Cytori Reports Preclinical and Mechanistic Data Supporting Use of Cytori Cell Therapy in Wounds Combining Thermal Burn and Radiation Exposure
Cytori Therapeutics, Inc. presented data from two preclinical studies funded through its contract with the United States Biomedical Advanced Research and Development Authority (BARDA) at the 2015 American Burn Association Meeting this week in Chicago. [Press release from Cytori Therapeutics, Inc. discussing research presented at the 2015 American Burn Association Meeting, Chicago] Press Release

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INDUSTRY NEWS
NeoStem Announces First Patient Randomized in Pivotal Phase III Melanoma Immunotherapy Clinical Trial
NeoStem, Inc. announced the randomization of the first patient in the Intus Phase III clinical trial investigating the efficacy of the Company’s patient-specific targeted cancer immunotherapy candidate NBS20 in patients with stage III recurrent or stage IV metastatic melanoma. [NeoStem, Inc.] Press Release

Bristol-Myers Squibb Receives Positive CHMP Opinion in the European Union for Opdivo (nivolumab) for the Treatment of Advanced Melanoma in Both First-Line and Previously Treated Patients
Bristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, be granted approval for use in both first-line and previously treated patients with advanced (unresectable or metastatic) melanoma. [Bristol-Myers Squibb] Press Release

SolaranRx’s SRX-1177 Receives FDA Orphan Drug Designation as Malignant Melanoma Treatment
SolaranRx announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to the company’s lead product, SRX-1177, for the treatment of stage IIB to IV malignant melanoma, a deadly form of skin cancer. [SolaranRx] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW World Congress of Dermatology 2015
June 8-13, 2015
Vancouver, Canada

NEW Cell Symposia: Cancer, Inflammation, and Immunity
June 14-16, 2015
Sitges, Spain

NEW 2015 World Stem Cell Summit
December 10-12, 2015
Atlanta, United States

Visit our events page to see a complete list of events in the dermal cell community.
 
JOB OPPORTUNITIES
NEW Professor – Dermatology (University of Wisconsin – Madison)

NEW Postdoctoral Fellow – Epidermal Growth, Inflammation and Carcinogenesis (Duke University School of Medicine)

NEW Chair of the Department of Dermatology (University of California, Davis)

NEW Faculty Positions – Stem Cell & Regenerative Medicine (University of Texas Medical School at Houston)

NEW Dermatology Specialty Representative (Celgene Corporation)

NEW Postdoctoral Positions – Molecular Cancer Biology (University of Pennsylvania)

NEW PhD Position – Decoding Gene Regulation in Cancer (University of Leuven)


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