Volume 6.24 | July 6

2020-07-06 | DCN 6.24
Dermal Cell News by STEMCELL Technologies
Vol. 6.24 – 6 July, 2020

Dietary Glutamine Supplementation Suppresses Epigenetically-Activated Oncogenic Pathways to Inhibit Melanoma Tumor Growth

Investigators showed that dietary glutamine supplementation significantly inhibited melanoma tumor growth, prolonged survival in a transgenic melanoma mouse model, and increased sensitivity to a BRAF inhibitor.
[Nature Communications]

Full Article

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A Novel Mechanism in Wound Healing: Laminin 332 Drives MMP9/14 Activity by Recruiting Syndecan-1 and CD44

By directly recruiting both syndecan-1 and CD44, laminin-332 G45 domain played a major role in regulating mechanisms underlying keratinocyte / extracellular matrix remodelling during wound repair.
[Matrix Biology]

Full Article

Cytotoxic and Genotoxic Effects on Human Keratinocytes Triggered by Sphingomyelinase D from Loxosceles Venom

Researchers investigated the cytotoxic and genotoxic effects caused by Loxosceles laeta venom and sphingomyelinase D on human keratinocytes to better understand the dermonecrosis development mechanism.
[Archives of Toxicology]


Melanoma Stem Cell Maintenance and Chemo-Resistance Are Mediated by CD133 Signal to PI3K-Dependent Pathways

The functional analysis of CD133+ and CD133 cells in vitro and in vivo revealed that melanoma progression and treatment resistance were the consequences of CD133 signal to PI3K pathway.


Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway

Researchers demonstrated that phenformin suppressed tumor growth and promoted keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model.
[Journal of investigative Dermatology]


Chondroitin Polymerizing Factor (CHPF) Promotes Development of Malignant Melanoma through Regulation of CDK1

Scientists demonstrated that chondroitin polymerizing factor was up-regulated in malignant melanoma tissues compared with the adjacent normal skin tissues and its high expression was correlated with more advanced T stage.
[Cell Death & Disease]

Full Article

CD38 in Cancer-Associated Fibroblasts Promotes Pro-Tumoral Activity

CAF-CD38 promoted migration of primary fibroblasts toward melanoma cells. Further, in vitro paracrine effects of CAF-CD38 fostered tumor cell migration and invasion as well as endothelial cell tube formation.
[Laboratory investigation]


Geometric Regulation of Histone State Directs Melanoma Reprogramming

Scientists uncovered a relationship between geometric features at perimeter regions of melanoma aggregates, and reprogramming to a stem cell-like state through histone marks H3K4Me2 and H3K9Ac.
[Communications Biology]

Full Article

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Burns in the Elderly: Potential Role of Stem Cells

The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences]

Full Article


Clinical Trials of Cryopreserved Umbilical Cord TTAX01 Allograft to Treat Complex Wagner Grade III-IV Diabetic Foot Ulcers

Amniox Medical, Inc announced the initiation of the first of two planned multi center randomized controlled Phase III clinical trials that will be conducted at 20 investigational sites across the U.S with an enrollment of 220 patients in each trial. These trials will study the benefits and risks of using TTAX01 to achieve complete wound closure of complex non-healing diabetic foot ulcers with high-risk factors of ulcer depth indicating exposed bone, tendon, muscle, and/or joint capsule, and clinical suspicion of osteomyelitis.

Press Release

Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]


United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.



The New York Stem Cell Foundation (NYSCF) Conference

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Postdoctoral Fellow – Novel Melanoma Therapies (Villanueva Lab)

The Wistar Institute – Philadelphia, Pennsylvania, United States

Postdoctoral Research Associate – Epitope Discovery (Melanoma/Pancreatic Adenocarcinoma)

King’s College London – London, United Kingdom

Product Manager – Melanoma

Bristol Myers Squibb – Montréal, Quebec, Canada

Postdoctoral Associate – Melanoma

The Hormel Institute – Austin, Minnesota, United States

Postdoctoral Fellowship – Dermatology

Brigham and Women’s Hospital – Boston, Massachusetts, United States

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